{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:57:12Z","timestamp":1761919032904,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; Genome-wide sequences of hepatitis B virus strain associated with type B fulminant hepatitis have not been compared with those of acute self-limited hepatitis. We carried out full-length sequencing analysis of viral strains derived from patients with type B acute liver injury. &lt;i&gt;Methods:&lt;\/i&gt; Nine acute self-limited hepatitis and 6 fulminant hepatitis patients were the subjects of this study. Full-length sequencing analysis of viral DNA was done by PCR-direct sequencing. &lt;i&gt;Results:&lt;\/i&gt; Higher frequencies in fulminant hepatitis strains compared with acute hepatitis ones were observed in the T1762\/A1764 (p &lt; 0.05), A1896 (p = 0.09) and M1753 (M = C or A) (p = 0.09) mutations. Viruses related to fulminant hepatitis possessed the higher number of nucleotide substitutions than those related to acute hepatitis in the whole virus genome (p &lt; 0.01) and various regions including preS\/S gene (p &lt; 0.05), precore\/core gene (p &lt; 0.01), polymerase gene (p &lt; 0.05) and basic core promoter\/core upstream regulatory sequence (p &lt; 0.01). The high number of nucleotide substitutions in viruses related to fulminant hepatitis was predominantly non-synonymous in the preS\/S and precore\/core genes. &lt;i&gt;Conclusion:&lt;\/i&gt; Development of type B fulminant hepatitis may be associated with a highly mutated hepatitis B virus strain.<\/jats:p>","DOI":"10.1159\/000110651","type":"journal-article","created":{"date-parts":[[2007,10,31]],"date-time":"2007-10-31T14:57:57Z","timestamp":1193842677000},"page":"394-401","source":"Crossref","is-referenced-by-count":13,"title":["Type B Fulminant Hepatitis Is Closely Associated with a Highly Mutated Hepatitis B Virus Strain"],"prefix":"10.1159","volume":"50","author":[{"given":"Aimi","family":"Kanada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Takehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Ohkawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohide","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryotaro","family":"Sakamori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinjiro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Kohga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Sasakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Hikita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taizo","family":"Hijioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matsuo","family":"Deguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Kagita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Kanto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hiramatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,10,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199312163292508"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2889%2990713-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199106133242404"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199106133242405"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.52.11.1630"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.21249"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006%2Fviro.1993.1257"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-9071%28199602%2948%3A2%3C171%3A%3AAID-JMV9%3E3.0.CO%3B2-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2893.1996.tb00092.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.510240203"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.510250633"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.2003.10835"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1099%2F0022-1317-69-10-2575"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.39.9.3200-3203.2001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fnar%2F11.13.4601"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01731581"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fbib%2F5.2.150"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.89.7.2708"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI119037"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.20553"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/110651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/110651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:08:01Z","timestamp":1745460481000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000110651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2008,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000110651","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"type":"print","value":"0300-5526"},{"type":"electronic","value":"1423-0100"}],"subject":[],"published":{"date-parts"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