{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:39:12Z","timestamp":1791031152906,"version":"4.1.0"},"reference-count":6,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogenic mutations cause early-onset AD and gene alleles have been suggested as AD susceptibility factors, the only extensively validated susceptibility gene for late-onset AD is the apolipoprotein E (&lt;i&gt;APOE)&lt;\/i&gt; &amp;#917;4 allele. Alleles of the &lt;i&gt;APOE&lt;\/i&gt; gene do not account for all of the genetic load calculated to be responsible for AD predisposition. Recently, polymorphisms across the neuronal sortilin-related receptor &lt;i&gt;(SORL1)&lt;\/i&gt; gene were shown to be significantly associated with AD in several cohorts. Here we present the results of our large case-control whole-genome scan at over 500,000 polymorphisms which presents weak evidence for association and potentially narrows the association interval.<\/jats:p>","DOI":"10.1159\/000110789","type":"journal-article","created":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T11:04:42Z","timestamp":1194001482000},"page":"60-64","source":"Crossref","is-referenced-by-count":54,"title":["&lt;i&gt;Sorl1&lt;\/i&gt; as an Alzheimer\u2019s Disease Predisposition Gene?"],"prefix":"10.1159","volume":"5","author":[{"given":"Jennifer A.","family":"Webster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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A.","family":"Stephan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,11,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.262.18.2551"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpsyc.63.2.168"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1943"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1789.2004.00571.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000116984"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4088%2FJCP.v68n0419"}],"container-title":["Neurodegenerative 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