{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:34:27Z","timestamp":1759847667025,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,11,9]],"date-time":"2007-11-09T00:00:00Z","timestamp":1194566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,11,9]],"date-time":"2007-11-09T00:00:00Z","timestamp":1194566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Introduction:<\/i> Meconium aspiration produces airway obstruction and surfactant inhibition. Bronchoalveolar lavage (BAL) and surfactant replacement have been proposed as treatments for the syndrome. <i>Objective:<\/i> To evaluate the effect of BAL with normal saline followed by a supplementary dose of surfactant in a piglet model of meconium aspiration syndrome. <i>Methods:<\/i> 15 newborn piglets were used in the study. The animals were ventilated with fixed settings. After inhalation of 4 ml\/kg of diluted meconium, the piglets were randomized into three groups: group I (n = 5) \u2013 tracheal aspiration without BAL; group II (n = 5) \u2013 BAL with normal saline (15 ml\/kg), and group III (n = 5) \u2013 BAL with normal saline (15 ml\/kg) followed by a supplementary dose of surfactant (Curosurf\u00ae 100 mg\/kg). Arterial blood gas samples were obtained 30 min and 6 h after the inhalation of meconium. <i>Results:<\/i> A significant increase of PaO<sub>2 <\/sub>values at 6 h after treatment was only observed in group III (from 51 \u00b1 13 to 189 \u00b1 115 mm Hg; p = 0.04). At this time, PaO<sub>2<\/sub> in group III was significantly higher compared to group II (189 \u00b1 115 and 37 \u00b1 11 mm Hg, respectively; p = 0.023) and showed a borderline significance when compared to group I (p = 0.066). <i>Conclusion:<\/i> BAL with normal saline followed by a supplementary dose of surfactant may improve oxygenation in an experimental piglet model of meconium aspiration syndrome.<\/jats:p>","DOI":"10.1159\/000110866","type":"journal-article","created":{"date-parts":[[2007,11,9]],"date-time":"2007-11-09T09:07:07Z","timestamp":1194599227000},"page":"188-192","source":"Crossref","is-referenced-by-count":6,"title":["Bronchoalveolar Lavage plus Surfactant in a Piglet Model of Meconium Aspiration Syndrome"],"prefix":"10.1159","volume":"93","author":[{"given":"Mauricio Obal","family":"Colvero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto Holmer","family":"Fiori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Machado","family":"Fiori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Hecker","family":"Luz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davi","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Oppermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo M\u00e1rcio","family":"Pitrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Duval","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Pieruccini","family":"Colvero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,11,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000084877"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02532529"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2898%2970482-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000084879"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199206000-00017"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199811000-00013"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00408-004-2505-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186%2Fcc302"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.103.5.1014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000049514.02607.03"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/110866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/110866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:10:05Z","timestamp":1745460605000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000110866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,9]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000110866","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2007,11,9]]}}}