{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:40:11Z","timestamp":1745462411568,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>Fistulas are common in Crohn\u2019s disease. A population-based study has shown a cumulative risk of 33% after 10 years and 50% after 20 years. Perianal fistulas were the most common (54%). Medical therapy is the main option for perianal fistula once abscesses, if present, have been drained, and should include antibiotics (both ciprofloxacin and metronidazole) and immunomodulators. Infliximab should be reserved for refractory patients. Surgery is often necessary for internal fistulas.<\/jats:p>","DOI":"10.1159\/000111024","type":"journal-article","created":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T10:26:52Z","timestamp":1201861612000},"page":"109-112","source":"Crossref","is-referenced-by-count":21,"title":["Fistulizing Crohn\u2019s Disease"],"prefix":"10.1159","volume":"76","author":[{"given":"Christian","family":"Felley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mottet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Juillerat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Pittet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Froehlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John-Paul","family":"Vader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Michetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Jacques","family":"Gonvers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,2,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.gastro.2003.08.025"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000083868"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.14.11.865"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.21.6.525"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2002.32362"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198005013021801"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01318372"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199905063401804"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa030815"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1542-3565%2804%2900414-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.01.048"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2003.01790.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02090211"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.1998.00442.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2803%2900877-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02054227"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02068077"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dig\/article-pdf\/76\/2\/109\/4033306\/000111024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/76\/2\/109\/4033306\/000111024.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:11:41Z","timestamp":1745460701000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000111024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,2,1]]},"published-print":{"date-parts":[[2007,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000111024","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2007]]}}}