{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:41:48Z","timestamp":1772084508507,"version":"3.50.1"},"reference-count":38,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T00:00:00Z","timestamp":1195171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T00:00:00Z","timestamp":1195171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Several studies have demonstrated the efficiency and safety of mild hypothermia (33\u00b0C) used for treating moderate encephalopathy. In animal models, deep hypothermia proved to be neuroprotective. &lt;i&gt;Objectives:&lt;\/i&gt; To determine the safety of whole-body deep hypothermia between 30 and 33\u00b0C in moderate-severe hypoxic-ischemic encephalopathy in newborn term infants. &lt;i&gt;Methods:&lt;\/i&gt; Mortality rates, incidence of brain damage detected by magnetic resonance imaging (MRI) and neurological outcomes of 39 term asphyxiated infants were retrospectively compared. A first group of patients (control group C) was treated with routine standard methods, a second group (MH) was treated with mild whole-body hypothermia (32\u201334\u00b0C) and a third group (DH) was treated with deep whole-body hypothermia (30\u201333\u00b0C), for 72 h. Mean arterial pH, basic excess (BE) and lactic acid in the blood were measured. Laboratory and clinical side effects of hypothermia were investigated. A conventional brain MRI was performed after the second week of life. &lt;i&gt;Results:&lt;\/i&gt; 39 term asphyxiated newborns were enrolled in the study: 11 in group C, 10 in group MH, and 18 in group DH. During the first 72 h, disseminated intravascular coagulation was recorded in 2 cases (18%) in group C, pulmonary hypertension in 2 patients (20%) in group MH, and pneumonia in 3 cases (16%) in group DH. Severe cerebral lesions and poor neurological outcome were observed in 4 cases (36%) in group C, 1 case (10%) in group MH, and 1 case (5%) in group DH. A statistically significant difference in brain damage and major clinical neurological abnormalities was observed between group C and groups MH and DH, whereas no differences were demonstrated between asphyxiated infants treated with mild or deep hypothermia. &lt;i&gt;Conclusions:&lt;\/i&gt; The results support the safety of deep hypothermia. Further studies are needed to confirm these results and the neuroprotective effect of this approach.<\/jats:p>","DOI":"10.1159\/000111101","type":"journal-article","created":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T12:15:42Z","timestamp":1195215342000},"page":"230-235","source":"Crossref","is-referenced-by-count":29,"title":["Safety of Deep Hypothermia in Treating Neonatal 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