{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:40:51Z","timestamp":1773326451637,"version":"3.50.1"},"reference-count":26,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Facial psoriasis requires a treatment approach other than topical corticosteroids which bear the risk of skin atrophy. Topical pimecrolimus has been shown to be effective in atopic eczema and recently in psoriasis. &lt;i&gt;Objective:&lt;\/i&gt; The aim of this open-label single-center investigator-initiated study was to evaluate the efficacy and safety of pimecrolimus 1% cream in patients with facial psoriasis. &lt;i&gt;Methods:&lt;\/i&gt; 20 adults with facial psoriasis were enrolled. Pimecrolimus 1% cream was applied twice daily to psoriatic lesions of the face over an 8-week period. An 8-week follow-up was added. &lt;i&gt;Results:&lt;\/i&gt; All clinical parameters showed a significant improvement after 8 and 16 weeks compared to baseline. Pimecrolimus 1% cream was effective and well tolerated. &lt;i&gt;Conclusions:&lt;\/i&gt; This is the first clinical study with a larger patient cohort reporting a relevant therapeutic effect and favorable safety profile of pimecrolimus 1% cream in facial psoriasis.<\/jats:p>","DOI":"10.1159\/000111510","type":"journal-article","created":{"date-parts":[[2008,1,28]],"date-time":"2008-01-28T07:48:52Z","timestamp":1201506532000},"page":"133-136","source":"Crossref","is-referenced-by-count":37,"title":["Pimecrolimus 1% Cream in the Treatment of Facial Psoriasis: A 16-Week Open-Label Study"],"prefix":"10.1159","volume":"216","author":[{"given":"Arnd","family":"Jacobi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Braeutigam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Mahler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hertl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,1,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature05663"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2004.06009.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2003.169"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2003.05426.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2005.01122.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2001.110046"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2003.05228.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.141.9.1154"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2004.07.011"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.142.9.1138"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1468-3083.2003.00692.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2002.122187"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0906-6705.2004.00269.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1368-5031.2005.00587.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1998.02554.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080%2F00015550310003791"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2004.06.010"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.1994.tb01167.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2005.06544.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2004.01054.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000070939"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.134.9.1101"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2004.01070.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2803%2901870-X"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159%2F000093860"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159%2F000100879"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:17:06Z","timestamp":1745461026000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000111510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000111510","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}