{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:56:53Z","timestamp":1745470613174,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background\/Aims:<\/i> The <i>JAK2<\/i><sup>V617F<\/sup> mutation, which has been found in patients with myeloproliferative disorders (MPD), has not yet been evaluated in lymphoproliferative disor- ders by any adequately sensitive techniques. <i>Methods:<\/i> We investigated whether low levels of <i>JAK2<\/i><sup>V617F<\/sup> are present in lymphoid neoplasms using a highly sensitive and highly specific amplification refractory mutation system PCR (ARMS-PCR) assay. <i>Results:<\/i> While 234 of 237 cases did not carry the <i>JAK2<\/i><sup>V617F<\/sup> allele, it was identified in the bone marrow of 3 B cell lymphoma patients. The mutation was found to be neither associated with the lymphomas per se, nor with any signs, symptoms or laboratory findings of MPD. Moreover, <i>JAK2<\/i><sup>V617F<\/sup> appeared subsequently in the peripheral blood of 2 of the 3 patients. <i>Conclusion:<\/i> These findings suggest that <i>JAK2<\/i><sup>V617F<\/sup> arises in the bone marrow of individuals before clinical manifestation of any myeloid disorders. Presence of <i>JAK2<\/i><sup>V617F<\/sup> in bone marrow might therefore increase the risk of future MPD development, just as monoclonal gammopathy of undetermined significance (MGUS) increases the risk of multiple myeloma. We term this phenomenon \u2018<i>JAK2<\/i><sup>V617F<\/sup> of undetermined significance\u2019 (JMUS). Its clinical significance remains to be determined. To our knowledge, these findings represent the first identification of <i>JAK2<\/i><sup>V617F<\/sup> in the bone marrow of patients without myeloid malignancies.<\/jats:p>","DOI":"10.1159\/000111532","type":"journal-article","created":{"date-parts":[[2007,11,23]],"date-time":"2007-11-23T11:08:56Z","timestamp":1195816136000},"page":"209-214","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of <i>JAK2<\/i><sup>V617F<\/sup> in B and T Cell Neoplasms: Identification of <i>JAK2<\/i><sup>V617F<\/sup> Mutation of Undetermined Significance (JMUS) in the Bone Marrow of Three Individuals"],"prefix":"10.1159","volume":"118","author":[{"given":"Y. Lynn","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joong W.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan S.","family":"Kui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Chadburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas C.P.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morton","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-04-4263"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404104"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature03546"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-03-1320"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa051113"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ccr.2005.03.023"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2006.06206.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-05-1800"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404026"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-03-1183"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2007.06497.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080%2F10428190500271723"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-06-029769"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2353%2Fjmoldx.2007.060133"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404206"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2006.06483.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404007"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-03-009472"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404854"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404724"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:17:22Z","timestamp":1745461042000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000111532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000111532","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2007]]}}}