{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:07:27Z","timestamp":1761718047323,"version":"3.40.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T00:00:00Z","timestamp":1196726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T00:00:00Z","timestamp":1196726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt; The aim of this retrospective study was to evaluate the clinical usefulness of the thyrotropin-releasing hormone (TRH) test in children with suspected hypothalamic or pituitary dysfunction. &lt;i&gt;Methods:&lt;\/i&gt; We reviewed the case notes of all patients in whom a TRH test had been performed over a 6-year period. Group 1 (n = 85, 34 males, aged 0.9\u201318.8 years) was the reference group with no evidence of hypothalamic, pituitary or thyroid dysfunction. Group 2 (n = 42, 24 males, 0.1\u201318.0 years) were being investigated for possible pituitary or hypothalamic insufficiency. &lt;i&gt;Results:&lt;\/i&gt; In Group 1, thyrotropin (TSH) responses were higher in females than males (p &lt; 0.01). In Group 2, TSH responses were normal for gender in 26 patients, subnormal in 5, and exaggerated\/delayed in 11. Four patients with normal TSH responses and 4 with exaggerated\/delayed responses had persistently low free thyroxine (FT&lt;sub&gt;4&lt;\/sub&gt;) or later developed low FT&lt;sub&gt;4&lt;\/sub&gt; and were treated with thyroxine. All those with subnormal TSH responses had normal FT&lt;sub&gt;4&lt;\/sub&gt; and were not treated. The TRH test did not reliably discriminate between hypothalamic and pituitary disorders. &lt;i&gt;Conclusions:&lt;\/i&gt; The TRH test did not give useful clinical information. Clinical decisions regarding thyroxine treatment were based on FT&lt;sub&gt;4&lt;\/sub&gt;, not the TRH test. The TRH test should be abandoned in paediatric practice.<\/jats:p>","DOI":"10.1159\/000111796","type":"journal-article","created":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T16:30:31Z","timestamp":1196958631000},"page":"53-59","source":"Crossref","is-referenced-by-count":1,"title":["An Evaluation of the Thyrotrophin-Releasing Hormone Stimulation Test in Paediatric Clinical Practice"],"prefix":"10.1159","volume":"69","author":[{"given":"Patricia M.","family":"Crofton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie A.","family":"Tepper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.H.","family":"Kelnar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-31-1-109"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-33-4-573"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-35-6-825"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-33-6-999"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2872%2990518-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-37-4-595"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2882%2980435-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1992.tb00947.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1992.tb00946.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000075239"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.2000.00996.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-030943"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.12.4472"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2871%2990005-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-48-6-989"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.134.1.432"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.138.9.3587"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.2.791"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1974.tb01787.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-34-2-380"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-42-5-809"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-37-2-190"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-43-2-394"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.80.2.679"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.10.3631"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11102-006-6042-4"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-020380"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111796","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:20:10Z","timestamp":1745461210000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000111796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,4]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000111796","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2007,12,4]]}}}