{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:32:47Z","timestamp":1790670767826,"version":"4.1.0"},"reference-count":9,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T00:00:00Z","timestamp":1196208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T00:00:00Z","timestamp":1196208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> Patients with obstructive sleep apnea syndrome (OSAS) often complain of dryness of mouth and throat prior to and during nasal continuous positive airway pressure (nCPAP). It is believed that this is due to mouth breathing (MB). However, the association between mouth breathing and apneas\/hypopneas and the effect of CPAP on MB has not been studied. <i>Objectives:<\/i> The purpose of the present study was, therefore, to assess the frequency and duration of episodes of MB prior to and during treatment with nCPAP. <i>Methods:<\/i> MB was recorded prior to and during nCPAP with a closely fitting mouth mask connected to a pneumotachograph and nasal flow was measured via nasal prongs. MB episodes were expressed as the number of events divided by total sleep time \u00d7 60, to give the MB event index per hour of sleep. MB time divided by total sleep time \u00d7 60 was calculated in minutes to get the MB time index per hour of sleep. <i>Patients:<\/i> Eleven male patients with OSAS (mean age 57.9 \u00b1 8.3 years, body mass index 30.2 \u00b1 3.8) were recruited to the study. <i>Results:<\/i> Prior to nCPAP, the apnea\/hypopnea index was 55.8 \u00b1 26 and decreased during nCPAP to 8.0 \u00b1 3.4. The lowest SaO<sub>2<\/sub> measured was 82.9 \u00b1 4.7%, and increased to 87.5 \u00b1 2.7% under nCPAP. The mean nCPAP was 7.8 \u00b1 1.6 cm H<sub>2<\/sub>O. MB event index per hour of sleep decreased from 35.2 \u00b1 19.7 prior to treatment to 5.0 \u00b1 5.2 under nCPAP (p < 0.01). In 52.2 \u00b1 27.4% of obstructive respiratory events, MB started at the end of an apnea\/hypopnea episode, decreasing to 8.5 \u00b1 12.5% with nCPAP treatment. MB time index per hour of sleep was reduced from 13.5 \u00b1 10.2 min prior to treatment to 4.6 \u00b1 5.5 min under nCPAP (p < 0.05). <i>Conclusions:<\/i> In OSAS patients, MB episodes often appear at the termination of an apnea\/hypopnea episode. In many cases, MB episodes can be markedly reduced by nCPAP treatment. When patients on nCPAP complain of dry mouth, appropriate measurements should be performed to verify MB.<\/jats:p>","DOI":"10.1159\/000111806","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T15:20:11Z","timestamp":1196176811000},"page":"40-45","source":"Crossref","is-referenced-by-count":32,"title":["Mouth Breathing in Obstructive Sleep Apnea prior to and during Nasal Continuous Positive Airway Pressure"],"prefix":"10.1159","volume":"76","author":[{"given":"Karl Heinz","family":"Ruhle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Nilius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.126.4.1248"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000079644"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.50.11.1179"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F00016489950180315"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.99.14612519"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.107.6.1552"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.99.14612419"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000089836"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.53.4.290"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:20:21Z","timestamp":1745461221000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000111806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,28]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000111806","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,28]]}}}