{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:33:22Z","timestamp":1787067202497,"version":"build-2736575974"},"reference-count":12,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T00:00:00Z","timestamp":1196208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T00:00:00Z","timestamp":1196208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> A wide range of drugs are commonly used to treat bronchiolitis, but evidence of their effectiveness is limited. <i>Objectives:<\/i> To investigate the efficacy of ipratropium bromide and salbutamol in the treatment of patients with moderate-severe bronchiolitis. <i>Methods:<\/i> Sixty-nine infants with moderate-severe bronchiolitis hospitalized at their first episode of wheezing or crepitations in the chest were enrolled in a prospective, double-blind, placebo-controlled trial. Patients were randomly assigned to receive nebulized salbutamol, ipratropium bromide or placebo. Main outcome measures were changes in oxygen saturation rates and clinical scores and duration of hospitalization. <i>Results:<\/i> In the bronchodilator groups, clinical scores were better compared to the placebo group at 30 min (8.4 \u00b1 1.3 vs. 7.5 \u00b1 0.8, p < 0.05). Bronchodilator groups had also significantly lower clinical scores (7.3 \u00b1 1.2 vs. 5.9 \u00b1 1.1, p < 0.0001, and 5.3 \u00b1 1.4 vs. 4.5 \u00b1 1.6, p = 0.006, respectively) and higher oxygen saturation rates compared to the placebo group at 8 and 24 h (89.6 \u00b1 2.4 vs. 94.3 \u00b1 4.4, and 92.2 \u00b1 2.6 vs. 95.9 \u00b14.4, respectively, p < 0.0001). Improvement rates and duration of hospitalization were not statistically different among groups. <i>Conclusions:<\/i> Clinical scores and oxygen saturation levels improved more rapidly in the bronchodilator groups than in the placebo group up to 24 h, but these drugs did not have a sufficient effect to change the natural course of the disease.<\/jats:p>","DOI":"10.1159\/000111817","type":"journal-article","created":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T08:05:06Z","timestamp":1196237106000},"page":"283-287","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of Salbutamol and Ipratropium Bromide in the Management of Acute Bronchiolitis \u2013 A Clinical Trial"],"prefix":"10.1159","volume":"76","author":[{"given":"Bulent","family":"Karadag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Ceran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsah","family":"Guven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esengul","family":"Dursun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilke Ozahi","family":"Ipek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazilet","family":"Karakoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Refika Hamutcu","family":"Ersu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulkadir","family":"Bozaykut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savas","family":"Inan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Dagli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2803%2912791-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.111.1.e45"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.87.6.546"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0929-693X%2896%2989885-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186%2Fcc1466"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.100.2.233"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.58.4.279"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.67.3.289"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2890%2991314-Z"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.66.9.1061"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00006454-199705000-00004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMe030052"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:20:32Z","timestamp":1745446832000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000111817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,28]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000111817","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,28]]}}}