{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:57:04Z","timestamp":1745470624548,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T00:00:00Z","timestamp":1196380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T00:00:00Z","timestamp":1196380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Family and twin studies suggest predisposing genetic factors in stroke. Lacunar infarcts represent a homogeneous phenotype, which is a prerequisite for genetic analyses. Applying an affected sib -pair analysis, we prospectively assessed the prevalence of microangiopathic brain lesions (MBL) and associated risk factors among siblings of patients with lacunar stroke. &lt;i&gt;Methods:&lt;\/i&gt; Index patients fulfilled clinical criteria of a lacunar stroke in combination with a corresponding MBL on CT or MRI. Siblings were characterized as affected if MBL demonstrated on MRI. The prevalence of MBL was compared with population prevalence data extracted from other studies. &lt;i&gt;Results:&lt;\/i&gt; From 784 patients screened, 81 index patients with lacunar stroke and 97 siblings were recruited, of which 42% were identified as affected. Compared with data from unselected historical controls and stratified by age groups, prevalence was between 2 and 5 times higher. &lt;i&gt;Conclusions:&lt;\/i&gt; Our results indicate that genetic stroke studies are feasible even in subtypes of ischemic stroke. The high prevalence of MBL among siblings of patients with lacunar infarct might suggest a familial aggregation. However, due to the small sample size these results need to be interpreted with caution and require confirmation by planned genetic analyses.<\/jats:p>","DOI":"10.1159\/000111877","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T14:43:15Z","timestamp":1196433795000},"page":"143-147","source":"Crossref","is-referenced-by-count":4,"title":["Increased Prevalence of Microangiopathic Brain Lesions among Siblings of Patients with Lacunar Stroke"],"prefix":"10.1159","volume":"59","author":[{"given":"Stefanie","family":"Leistner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Huebner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Faulstich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren","family":"Rees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Marx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Langer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandrina","family":"Nikolova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Christian","family":"Koennecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,11,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0896-429"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2Fhs0302.103619"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000069723.17984.FD"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F123.9.1784"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000035261.28528.C8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000049146"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.1991.tb04675.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000038424.70926.5E"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000125859.71051.83"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2Fhs1101.098524"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000077337"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawf077"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.55.9.1217"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2Fhs0102.101629"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000080934.68280.82"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161%2Fhs1201.099795"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000058486.68044.3B"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000252955.17126.6a"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:21:18Z","timestamp":1745461278000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000111877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,30]]},"references-count":18,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2008,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000111877","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"type":"print","value":"0014-3022"},{"type":"electronic","value":"1421-9913"}],"subject":[],"published":{"date-parts":[[2007,11,30]]}}}