{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:58:46Z","timestamp":1769147926746,"version":"3.49.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T00:00:00Z","timestamp":1196726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T00:00:00Z","timestamp":1196726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Objective:<\/i> Debates about adverse effects of ventricular- vs. atrial-based pacing have never ended, especially regarding cardiovascular outcomes in common pacemaker populations. <i>Methods:<\/i> To investigate the contribution of right ventricular apical pacing to the left ventricular negative remodeling, we measured the inter- and intraventricular mechanical dyssynchrony by echocardiography as well as plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) level in 116 consecutive patients of symptomatic bradyarrhythmias including sinus node dysfunction (SND) in 80 and atrioventricular block in 36. Dual-chamber rate-modulated pacing (DDDR) pacemakers were implanted in 76 patients (SND, 40), and single-chamber ventricular rate-modulated pacing (AAIR) pacemakers in 40 (all SND). Clinical manifestations were retrospectively correlated. <i>Results:<\/i> After 3.5 years of pacing, DDDR pacemaker patients demonstrated higher plasma NT-proBNP concentration (503 \u00b1 111 pg\/ml) than AAIR patients (194 \u00b1 42 pg\/ml, p = 0.002) despite similar cardiovascular function at baseline. Multivariate regression analysis revealed that the only predictor of the highest quartile of plasma NT-proBNP, i.e. \u2267386 pg\/ml, was the interventricular contraction time difference (p = 0.01). Reprograming to minimize ventricular pacing percentage in 8 patients of SND caused parallel reduction of plasma NT-proBNP. <i>Conclusion:<\/i> Interventricular mechanical dyssynchrony, imposed mostly by right ventricular apical pacing, could lead to abnormal heightening of plasma NT-proBNP concentration after chronic DDDR pacing in common pacemaker patients with normal baseline left ventricular function.<\/jats:p>","DOI":"10.1159\/000111926","type":"journal-article","created":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T16:30:31Z","timestamp":1196958631000},"page":"167-173","source":"Crossref","is-referenced-by-count":3,"title":["Interventricular Mechanical Dyssynchrony Determines Abnormal Heightening of Plasma N-Terminal Probrain Natriuretic Peptide Level in Symptomatic Bradyarrhythmia Patients with Chronic Dual-Chamber vs. Single-Chamber Atrial Pacing"],"prefix":"10.1159","volume":"110","author":[{"given":"Jih-Min","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Ping","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Ti","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lung-Chun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuen-Den","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiunn-Lee","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9149%2891%2990437-P"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0735-1097%2894%2990567-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2896%2900389-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2897%2903425-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200005113421902"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2803%2900757-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa013040"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000072769.17295.B1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.288.24.3115"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.2005.071233"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2003.08.038"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2004.12.032"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehi657"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199804163381602"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa042283"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.105.610303"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.105.608356"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2802%2902059-4"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:21:52Z","timestamp":1745461312000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000111926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,4]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000111926","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,4]]}}}