{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T17:22:01Z","timestamp":1772472121325,"version":"3.50.1"},"reference-count":4,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,12,4]],"date-time":"2006-12-04T00:00:00Z","timestamp":1165190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,12,4]],"date-time":"2006-12-04T00:00:00Z","timestamp":1165190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; We compared a novel vaginal tablet consisting of 100 mg of clotrimazole and 100 mg of metronidazole (\u2018Clo-Met\u2019) to a 100-mg clotrimazole tablet in the treatment of vaginitis. &lt;i&gt;Methods:&lt;\/i&gt; A multicenter, double-blind, randomized controlled study. Women with vaginal discharge and diagnosed as suffering from vaginitis caused by &lt;i&gt;Trichomonas vaginalis,&lt;\/i&gt; bacterial vaginosis or &lt;i&gt;Candida albicans,&lt;\/i&gt; or any combination of the three, and who had not received treatment for vaginitis during the previous month, were studied. &lt;i&gt;Results:&lt;\/i&gt; 165 patients were enrolled into the study \u2013 84 into the combined therapy group, and 81 into the clotrimazole group. In women with &lt;i&gt;Candida&lt;\/i&gt; vaginitis, Clo-Met was more effective than clotrimazole treatment (p &lt; 0.012 and p &lt; 0.05, respectively). &lt;i&gt;Conclusion:&lt;\/i&gt; A combination vaginal tablet consisting of clotrimazole and metronidazole is therapeutically effective in candidal vaginitis. The effectiveness of Clo-Met on bacterial vaginosis, &lt;i&gt;T. vaginalis&lt;\/i&gt; infection as well as on vaginal infections due to a combination of these microorganisms should be studied further.<\/jats:p>","DOI":"10.1159\/000111946","type":"journal-article","created":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T16:31:58Z","timestamp":1196958718000},"page":"195-200","source":"Crossref","is-referenced-by-count":4,"title":["A Universal Combination Treatment for Vaginitis"],"prefix":"10.1159","volume":"65","author":[{"given":"Jacob","family":"Bornstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doron","family":"Zarfati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11908-005-0048-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2004.02.015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198009113031102"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155%2FS1064744901000187"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/111946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:22:03Z","timestamp":1745461323000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000111946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,4]]},"references-count":4,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000111946","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,4]]}}}