{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:25:29Z","timestamp":1791321929158,"version":"4.3.1"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>Age is considered to be a major risk factor for atherosclerosis, but it is unclear whether age has a direct effect on susceptibility to atherosclerosis. Wild-type mice develop fatty streak lesions in the aortic root only when fed a cholate-containing high fat\/cholesterol diet. To investigate the influence of age on fatty streak formation, young (10 weeks) and old (53 weeks) female C57BL\/6 mice were fed an atherogenic diet containing 15% fat, 1.25% cholesterol and 0.5% sodium cholate for 12 weeks. Atherosclerotic lesions at the aortic root were measured after cryosections were stained with oil red O. Results showed that old mice developed a comparable size of aortic lesions with young counterparts (5,600 \u00b1 2,480 vs. 6,457 \u00b1 1,537 \u00b5m&lt;sup&gt;2&lt;\/sup&gt;\/section; p = 0.77), although old mice had significantly higher plasma cholesterol levels than young mice on the atherogenic diet (p &lt; 0.05). Plasma levels of soluble vascular cell adhesion molecule 1 were significantly higher in old mice than in young mice on both chow and Western diets (p &lt; 0.005). These data indicate that age has no direct effect on atherosclerosis susceptibility although it is accompanied by elevations in plasma cholesterol and vascular cell adhesion molecule 1 levels in C57BL\/6 mice. Thus, increased cardiovascular events with age are probably related to a progressive increase in plaque size rather than to an increase in atherosclerosis susceptibility.<\/jats:p>","DOI":"10.1159\/000112133","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T05:31:44Z","timestamp":1197610304000},"page":"205-210","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Aging on Fatty Streak Formation in a Diet-Induced Mouse Model of Atherosclerosis"],"prefix":"10.1159","volume":"45","author":[{"given":"Yuhua","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan H.","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,12,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-9150%2891%2990003-L"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-5793%2802%2902902-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-9150%2887%2990202-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000015853.59427.32"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000013388.03553.31"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2005.02.090"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1534%2Fgenetics.105.051912"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2004.03.037"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nut.2005.04.002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-9150%2887%2990249-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.92.17.7729"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1538%2Fexpanim.53.159"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2249.2000.01281.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000172629.12846.b8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.051003698"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2006.04.180"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-5699%2893%2990267-O"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000071710"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.106.640185"}],"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:23:54Z","timestamp":1745447034000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000112133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,7]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000112133","archive":["Portico"],"relation":{},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"value":"1018-1172","type":"print"},{"value":"1423-0135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,7]]}}}