{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:19:35Z","timestamp":1760015975031,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T00:00:00Z","timestamp":1197244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T00:00:00Z","timestamp":1197244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Accumulating biological and epidemiological evidence suggests a close link between cholesterol metabolism and the pathophysiology of Alzheimer\u2019s disease (AD). The observation that the use of statins reduces the risk of AD sustains this hypothesis. Apolipoprotein A-I (APOA1) is the major component of the high-density lipoproteins, particles involved in reverse cholesterol transport. Therefore, genetic polymorphisms in the gene encoding APOA1 might influence cholesterol metabolism and be a risk factor for AD. A previous study suggested an impact of a G\u2192A polymorphism at position \u201375 bp in the &lt;i&gt;APOA1&lt;\/i&gt; gene on the risk for early-onset AD and on the age at onset of the disease. We studied this polymorphism in 3 independent European population samples. &lt;i&gt;Methods:&lt;\/i&gt; Genotyping was conducted asdescribed in the previous study. &lt;i&gt;Results:&lt;\/i&gt; We were unable to show any impact of this polymorphism on the risk of AD. Conversely, subjects bearing the A allele of this polymorphism were at risk of cognitive decline. &lt;i&gt;Conclusion:&lt;\/i&gt; Our resultssuggest an impact of the G\u2192A polymorphism at position \u201375 bp in the &lt;i&gt;APOA1&lt;\/i&gt; gene on cognitive impairment, but not on the risk of AD.<\/jats:p>","DOI":"10.1159\/000112176","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T10:31:44Z","timestamp":1197628304000},"page":"97-102","source":"Crossref","is-referenced-by-count":16,"title":["An &lt;i&gt;Apolipoprotein A-I&lt;\/i&gt; Gene Promoter Polymorphism Associated with Cognitive Decline, but Not with Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"25","author":[{"given":"Nicole","family":"Helbecque","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Codron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Cottel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Amouyel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4088%2FJCP.v67n1118"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1132814"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-003-0142-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.mp.4001854"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.2006.00691.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.2006.00687.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000090676"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2806%2970355-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1179%2F016164106X98035"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Faje%2Fkwm027"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2899%2900103-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.molbrainres.2003.08.005"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-9150%2896%2905966-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%2819990129%2982%3A3%3C235%3A%3AAID-AJMG8%3E3.0.CO%3B2-H"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20593"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0304-3940%2896%2913092-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00308809"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cccn.2005.04.004"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2005.05.008"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000132523.27540.81"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajgp.13.8.645"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000238517.59286.c5"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000130531.90205.EF"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:24:26Z","timestamp":1745461466000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000112176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,10]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000112176","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2007,12,10]]}}}