{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:25:58Z","timestamp":1776849958901,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[1985,9,25]],"date-time":"1985-09-25T00:00:00Z","timestamp":496454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[1985,9,25]],"date-time":"1985-09-25T00:00:00Z","timestamp":496454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Neurosci"],"abstract":"<jats:p>Male rats were exposed daily to ethanol vapour from 3 days of age, and their brains were examined at 7, 14, 21, 56 and 76 days postnatally. Control animals were examined at each age, and ethanol-rehabilitated animals were examined at 56 and 76 days postnatally. Tissue from the parietal cortex of each animal stained with osmium tetroxide and with ethanolic-phosphotungstic acid (E-PTA) was analyzed by qualitative ultra-structural techniques. The ethanol flow rate in the incubation chamber was adjusted to maintain the blood ethanol level as close as possible to 0.1 g\/100 ml. Ethanol-treated rats weighed less than ethanol-rehabilitated animals at days 56 and 76. At day 7 synapses were formed between axons and dendritic growth cones, dendritic shafts and filopodia in control and ethanol-treated tissue. At days 14 and 21 well-developed axodendritic and axospinous synapses were evident in both groups. The neuropil of 56- and 76-day-old material was similar in the control and treatment groups, except that there was an enlargement of dendritic profiles in the 56-day-old ethanol-treated material. Perforated synapses were most common in 56-day-old ethanol-treated material, with degenerating synapses most common in 56-day-old (and to a lesser extent 76-day-old) ethanol-rehabilitated material. No obvious differences were detected between any of the groups of the E-PTA-stained material. The presence of degenerating and perforated synapses suggests that synaptic remodelling is occurring, and this may be a means of adapting synaptic mechanisms to the functional demands imposed by ethanol.<\/jats:p>","DOI":"10.1159\/000112280","type":"journal-article","created":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T11:30:41Z","timestamp":1196940641000},"page":"94-106","source":"Crossref","is-referenced-by-count":14,"title":["Ultrastructural Investigation into the Influence of Ethanol on Synaptic Maturation in Rat Neocortex"],"prefix":"10.1159","author":[{"given":"D.G.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Colangelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1985,9,25]]},"container-title":["Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000112280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:27:18Z","timestamp":1776846438000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000112280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000112280","archive":["Portico"],"relation":{},"ISSN":["0378-5866","1421-9859"],"issn-type":[{"value":"0378-5866","type":"print"},{"value":"1421-9859","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,9,25]]}}}