{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:35:38Z","timestamp":1771054538918,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,12,12]],"date-time":"2007-12-12T00:00:00Z","timestamp":1197417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,12,12]],"date-time":"2007-12-12T00:00:00Z","timestamp":1197417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; No validated delivery technique exists for accurate, reproducible delivery of biological therapies to discrete spinal cord targets. To address this unmet need, we have constructed a stabilized platform capable of supporting physiologic mapping, through microelectrode recording, and cellular or viral payload delivery to the ventral horn. &lt;i&gt;Methods:&lt;\/i&gt; A porcine animal model (n = 7) has been chosen based upon the inherent morphologic similarities between the human and porcine spine. Animals underwent physiologic mapping and subsequent microinjection of a green-fluorescent-protein-labeled cell suspension. Sacrifice (t = 3 h) was performed immediately following behavioral assessment. &lt;i&gt;Results:&lt;\/i&gt; Histologic analysis has supported our ability to achieve localization to the ipsilateral ventral horn in the spinal cord. Complications included death due to malignant hyperthermia (n = 1), hindlimb dysfunction attributable to epidural hematoma (n = 1), and hindlimb dysfunction attributable to cord penetration (n = 2).&lt;i&gt; Conclusions:&lt;\/i&gt; These results indicate an ability to achieve accurate targeting, but the elevated incidence of neurologic morbidity will require further studies with longer follow-ups that incorporate procedural and equipment modifications that will allow for a reduced number of cord penetrations and will account for observed cardiorespiratory-associated cord movement. These initial results reinforce the challenges of translating biological restorative therapies from small to large animal models and ultimately to humans.<\/jats:p>","DOI":"10.1159\/000112426","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T10:31:44Z","timestamp":1197628304000},"page":"67-74","source":"Crossref","is-referenced-by-count":31,"title":["Targeted Spinal Cord Therapeutics Delivery: Stabilized Platform and Microelectrode Recording Guidance Validation"],"prefix":"10.1159","volume":"86","author":[{"given":"Jonathan","family":"Riley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth B.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shearwood","family":"McClelland III","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingshan","family":"Teng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Garrity-Moses","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thais","family":"Federici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas M.","family":"Boulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,12,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1227%2F01.NEU.0000219237.69329.B7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fmus.20418"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1086137"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20453"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1385%2FNMM%3A6%3A2-3%3A079"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186%2Fjbiol35"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.200308101"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20901"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fmus.20439"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0408258102"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1089%2Fneu.1995.12.1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainresprot.2005.01.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1986.65.4.0465"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1179%2F016164106X116791"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:27:42Z","timestamp":1745461662000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000112426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,12]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000112426","archive":["Portico"],"relation":{},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"value":"1011-6125","type":"print"},{"value":"1423-0372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,12]]}}}