{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:11:35Z","timestamp":1761894695959,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Introduction:<\/i> We performed a prospective, randomized study to examine the efficacies of levofloxacin and doxazosin alone and as a combination therapy in patients with National Institutes of Health (NIH) category III chronic prostatitis\/chronic pelvic pain syndrome. <i>Patients and Methods:<\/i> Men with a NIH diagnosis of category III chronic prostatitis\/chronic pelvic pain syndrome and who had experienced pelvic pain for more than 3 months during the last 6 months were enrolled. All patients underwent treatment for 6 weeks. The patients were assessed at baseline and after 2 and 6 weeks by using the NIH Chronic Prostatitis Symptom Index. Eighty-one men (average age 40.1 years) were randomized to either the levofloxacin group (n = 26), the doxazosin group (n = 26), or the combination group (n = 29). <i>Results:<\/i> The average baseline NIH Chronic Prostatitis Symptom Index total scores were 22.6, 22.4, and 24.1, respectively. At 6 weeks, the total scores were 11.2 (response rate 50.3%), 17.7 (response rate 21.1%), and 13.1 (response rate 45.6%), respectively. The levofloxacin group showed a higher response rate than the doxazosin group, not at 2 weeks but at 6 weeks (p < 0.001). <i>Conclusions:<\/i> For a 6-week short-term treatment levofloxacin is more effective than doxazosin for chronic prostatitis\/chronic pelvic pain syndrome. In addition, levofloxacin monotherapy was also more effective when compared with the combination therapy.<\/jats:p>","DOI":"10.1159\/000112606","type":"journal-article","created":{"date-parts":[[2008,3,25]],"date-time":"2008-03-25T07:07:12Z","timestamp":1206428832000},"page":"157-161","source":"Crossref","is-referenced-by-count":26,"title":["Treatment for Chronic Prostatitis\/ Chronic Pelvic Pain Syndrome: Levofloxacin, Doxazosin and Their Combination"],"prefix":"10.1159","volume":"80","author":[{"given":"Chang Wook","family":"Jeong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Jung","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwancheol","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,3,19]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016%2FS0022-5347%2801%2963564-X"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016%2FS0090-4295%2897%2900308-7"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1016%2FS0090-4295%2898%2900297-0"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1016%2FS0090-4295%2897%2900336-1"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1046%2Fj.1464-410X.2000.00836.x"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1016%2FS0022-5347%2801%2966359-6"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1016%2FS0022-5347%2805%2964686-1"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1111%2Fj.1442-2042.1998.tb00597.x"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1016%2FS0022-5347%2805%2963960-2"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1097%2F01.ju.0000117811.40279.19"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1016%2FS0090-4295%2803%2900466-7"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016%2FS0090-4295%2803%2900583-1"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1007%2FBF01643680"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1002%2Fpros.2990230204"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1159%2F000029906"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1016%2FS0022-5347%2805%2966344-6"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1016%2FS0090-4295%2898%2900390-2"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1159%2F000239480"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1159%2F000019784"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:29:40Z","timestamp":1745461780000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000112606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000112606","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2008]]}}}