{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:38:59Z","timestamp":1782553139956,"version":"3.54.5"},"reference-count":15,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Aims:<\/i> This study aims to explore the spectrum of renal disease in HIV-infected patients, identify clinical predictors of HIV-associated nephropathy (HIVAN), and investigate the performance of renal biopsy in HIV-infected patients. <i>Method:<\/i> Of 263 HIV-infected patients with renal disease evaluated between 1995 and 2004, 152 had a renal biopsy, while 111 had not. A group comparison was performed. <i>Results:<\/i> The leading biopsy diagnoses were HIVAN (35%), noncollapsing focal segmental glomerulosclerosis (22%), and acute interstitial nephritis (7.9%), amongst over a dozen others. There was a trend of decreasing yearly incidence of HIVAN diagnoses, paralleling the use of antiretroviral therapy. By multivariate logistic regression, CD4 counts >200 cells\/mm<sup>3<\/sup> and higher estimated glomerular filtration rate were strong negative predictors of HIVAN. HIVAN patients were more likely to require dialysis (p < 0.0001) and had worse overall survival (p = 0.02). Younger age and lower estimated glomerular filtration rate were significant predictors of renal biopsy in multivariate regression analysis. More biopsied patients progressed to dialysis (51 vs. 25%, p = 0.001) and death (15 vs. 5.4%, p = 0.001), despite more frequent corticosteroid treatment (29 vs. 3.6%, p = 0.001). <i>Conclusion:<\/i> These findings may reflect more severe acute and\/or chronic disease at the time of biopsy and suggests that earlier renal biopsy may be warranted in HIV-infected patients, especially in light of the changing spectrum of renal disease in this group.<\/jats:p>","DOI":"10.1159\/000112851","type":"journal-article","created":{"date-parts":[[2008,1,4]],"date-time":"2008-01-04T13:12:59Z","timestamp":1199452379000},"page":"478-486","source":"Crossref","is-referenced-by-count":103,"title":["Observations on a Cohort of HIV-Infected Patients Undergoing Native Renal Biopsy"],"prefix":"10.1159","volume":"28","author":[{"given":"Adam R.","family":"Berliner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek M.","family":"Fine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Hafizur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine C.","family":"Racusen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Scheel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed G.","family":"Atta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,1,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198403153101101"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053%2Fsnep.2003.50019"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2001.20738"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005040340"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5000351"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00865.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjmed.2005.05.027"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00002030-200402200-00022"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00094.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2924037-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2FQAD.0b013e3280119592"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfl337"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5000339"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1086%2F505497"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1086%2F503566"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:32:51Z","timestamp":1745461971000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000112851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000112851","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}