{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:32:48Z","timestamp":1789785168900,"version":"4.0.1"},"reference-count":19,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; \u03b2-Site amyloid precursor protein cleaving enzyme (BACE) is a candidate risk factor for Alzheimer\u2019s disease (AD) from its key role in \u03b2-amyloid generation. Previous genetic association studies of &lt;i&gt;BACE1&lt;\/i&gt; gene have yielded conflicting results. This study is an attempt to clarify whether the common SNP in exon 5 of &lt;i&gt;BACE1&lt;\/i&gt; (rs638405, Val262) is associated with a risk for late-onset AD. &lt;i&gt;Methods:&lt;\/i&gt; We genotyped a synonymous C\/G polymorphism of &lt;i&gt;BACE1&lt;\/i&gt; located in exon 5 and apolipoprotein E (ApoE) in 248 AD patients and 224 healthy persons. A meta-analysis with pooled data from four Chinese studies and our results was performed. &lt;i&gt;Results:&lt;\/i&gt; The allele and genotype frequencies of &lt;i&gt;BACE1&lt;\/i&gt; polymorphism were not significantly different between cases and controls (p &gt; 0.05) in the Korean population. A meta-analysis of previously published Asian populations including Koreans showed evidence of a weak association (p = 0.0555 for genotypes, p = 0.0352 for alleles). However, a significant association between the CC genotype and AD was observed in the ApoE-&amp;#917;4-positive groups (p = 0.0044, OR = 1.995; 95% CI = 1.319\u20133.018). &lt;i&gt;Conclusion:&lt;\/i&gt; These data suggest that BACE1 polymorphism in exon 5 influences risk for late-onset AD in those carrying the ApoE &amp;#917;4 allele.<\/jats:p>","DOI":"10.1159\/000112918","type":"journal-article","created":{"date-parts":[[2008,1,7]],"date-time":"2008-01-07T11:03:51Z","timestamp":1199703831000},"page":"165-169","source":"Crossref","is-referenced-by-count":13,"title":["Association of BACE1 Gene Polymorphism with Alzheimer\u2019s Disease in Asian Populations: Meta-Analysis Including Korean Samples"],"prefix":"10.1159","volume":"25","author":[{"given":"Sangmee A.","family":"Jo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungsook","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunkyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwa-Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inho","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doh Kwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsoo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-291X%2884%2980190-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2F990114"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.97.4.1456"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2F990107"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1006%2Fmcne.1999.0811"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.286.5440.735"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2Fddh077"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-200107030-00008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-003-1127-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.b.10010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-200307010-00011"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.b.20087"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1385%2FJMN%3A25%3A2%3A127"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2801%2902234-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-200103050-00040"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2802%2903849-0"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-200506210-00028"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.44.4.609"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1934"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:33:36Z","timestamp":1745462016000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000112918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000112918","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}