{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:46:21Z","timestamp":1759333581270,"version":"3.40.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; The guidelines of the British Photodermatology Group for topical treatment with psoralen and ultraviolet light (PUVA) recommend starting UVA doses between 0.2 and 0.5 J\/cm&lt;sup&gt;2&lt;\/sup&gt;, according to the phototype. Our purpose was to evaluate the therapeutic efficacy and tolerability of bath PUVA, with 8-methoxypsoralen (8-MOP), by using lower UVA doses, regardless of phototype. &lt;i&gt;Methods:&lt;\/i&gt; We compared 2 groups of patients (group 1: n = 10, group 2: n = 20) with chronic plaque-type psoriasis. Group 1 was treated with the usual starting dose and dose progression; group 2 was treated by using a lower first dose, a slower dose progression and reaching a lower maximum dose. The Psoriasis Area and Severity Index (PASI) score was assessed at the initial stages, and every month until the end of the treatment. &lt;i&gt;Results:&lt;\/i&gt; In group 1, the median baseline PASI score decreased from 15.2 to 4.5 (p &lt; 0.005, Student\u2019s paired t test), while in group 2, it fell from 13.7 to 4.1 (p &lt; 0.005). No statistical difference between the groups is detectable. Severe phototoxic reactions were observed only in 2 patients of group 1. Side effects were not observed in group 2. &lt;i&gt;Conclusions:&lt;\/i&gt; Our data indicate that an aggressive bath PUVA treatment is not substantially more effective in clearing chronic plaque-type psoriasis than a milder therapeutic approach.<\/jats:p>","DOI":"10.1159\/000112924","type":"journal-article","created":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T10:19:35Z","timestamp":1199873975000},"page":"191-193","source":"Crossref","is-referenced-by-count":7,"title":["Bath PUVA and Psoriasis: Is a Milder Treatment a Worse Treatment?"],"prefix":"10.1159","volume":"216","author":[{"given":"G.","family":"Delrosso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bornacina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Farinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bellinzona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Leigheb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,1,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0781.2001.170402.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2000.03237.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12496022"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2896%2990721-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.4.1225"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112924","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:33:42Z","timestamp":1745462022000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000112924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000112924","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2008]]}}}