{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:38:44Z","timestamp":1787974724012,"version":"build-2784847793"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Minocycline-induced drug rash with eosinophilia and systemic symptoms (DRESS) may have a prolonged course, especially in African and African-American patients. &lt;i&gt;Objectives:&lt;\/i&gt; To determine if a prolonged course of minocycline-induced DRESS was associated with an accumulation of the culprit drug. &lt;i&gt;Patients and Methods:&lt;\/i&gt; We determined plasma and skin levels of minocycline in patients with minocycline-induced DRESS. We investigated the genetic polymorphisms of enzymes potentially involved in the detoxification of the drug, glutathione S-transferases and UDP-glucuronosyltransferases. &lt;i&gt;Results and Conclusions:&lt;\/i&gt; We demonstrated the persistence of minocycline in the plasma and\/or in the skin of 7 out of 9 patients with skin phototypes V\u2013VI. As pigmented skin contains more melanin, this could promote the formation of a melanin-minocycline complex, which could explain the severe and prolonged DRESS which may occur in this subgroup of patients.<\/jats:p>","DOI":"10.1159\/000112926","type":"journal-article","created":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T05:19:35Z","timestamp":1199855975000},"page":"200-204","source":"Crossref","is-referenced-by-count":49,"title":["Minocycline-Induced DRESS: Evidence for Accumulation of the Culprit Drug"],"prefix":"10.1159","volume":"216","author":[{"given":"Eve","family":"Maubec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Wolkenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Anne","family":"Loriot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Wechsler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Mulot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Beaune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Revuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Roujeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,1,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1085-5629%2896%2980038-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2962446-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1525-1470.2001.01931.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1993.tb03519.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1989.tb01807.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1993.tb03166.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.124.6.869"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-4347%2897%2900647-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0560.1987.tb00493.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00008571-199810000-00009"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2165%2F00003088-198815060-00001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.136.3.323"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2165%2F00002018-199818060-00004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2880%2980186-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1515%2FCCLM.2002.167"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00008571-199604000-00005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-9150%2899%2900483-9"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:33:46Z","timestamp":1745447626000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000112926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000112926","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}