{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:13:30Z","timestamp":1792664010220,"version":"4.5.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background: &lt;\/i&gt;Chronic dermatoses, as well as S\u00e9zary syndrome (SS), the erythrodermic and leukaemic cutaneous T-cell lymphoma, display a T-cell memory pattern. Recent findings suggest that different memory T-cell subsets can be recognized based on CD27 and CD45RO\/RA expression. No data are reported as to CD27 expression in SS. &lt;i&gt;Objectives: &lt;\/i&gt;To evaluate different memory T-cell subsets, i.e. central memory (TCM), effector memory (TEM) and terminally differentiated cells in SS and inflammatory erythroderma (IE). &lt;i&gt;Materials and Methods: &lt;\/i&gt;Forty SS and 137 IE patients were included. CD27 and CD45RO\/CD45RA expression was analysed by flow cytometry on peripheral blood lymphocytes and immunohistochemistry.&lt;i&gt;Results: &lt;\/i&gt;A significantly higher expression of the CD4+CD27+CD45RA\u2013 TCM subset was observed in SS whilst IE patients were characterized by increased CD4+CD27\u2013CD45RA\u2013 TEM levels. The V\u03b2-restricted population was homogeneously CD4+CD26\u2013CD27+ in the SS subjects. &lt;i&gt;Conclusions: &lt;\/i&gt;SS and IE are characterized by a different memory T-cell subset expression; CD27 expression could be used as an additional diagnostic tool in the differential diagnosis.<\/jats:p>","DOI":"10.1159\/000112928","type":"journal-article","created":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T10:19:35Z","timestamp":1199873975000},"page":"213-221","source":"Crossref","is-referenced-by-count":28,"title":["Heterogeneity of Circulating CD4+ Memory T-Cell Subsets in Erythrodermic Patients: CD27 Analysis Can Help to Distinguish Cutaneous T-Cell Lymphomas from Inflammatory Erythroderma"],"prefix":"10.1159","volume":"216","author":[{"given":"M.T.","family":"Fierro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Novelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Quaglino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Comessatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ortoncelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ponti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.G.","family":"Bernengo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,1,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.immunol.22.012703.104702"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2567.2004.01974.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0105-2896.2006.00393.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mad.2005.11.001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clim.2005.03.020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.21943"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.1996.tb00030.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12280303"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1008397323199"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0889-8588%2803%2900120-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2005.06706.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2001.116224"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2004.01975.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2004.02100.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2001.04014.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000096191"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2002.19610.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2001.117722"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2002.118538"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2005.06649.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0560.2001.280704.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002%2Fpath.1133"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.141.5.642"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-3083.1998.00387.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:33:48Z","timestamp":1745462028000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000112928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000112928","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}