{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:14:54Z","timestamp":1783988094348,"version":"3.55.0"},"reference-count":11,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Objective:<\/i> The aim of the study was to evaluate the role of vitamin B<sub>12<\/sub> in patients with pernicious anemia. <i>Materials and Methods:<\/i> This study was conducted prospectively at the Turgut \u00d6zal Medical Center, Department of Hematology, between April and November 2002. Absolute numbers and ratio of the surface antigens of T and B lymphocyte subgroups, CD4\/CD8 ratio were calculated in order to evaluate changes in leukocyte and lymphocyte numbers; natural killer (NK) cell count, serum C3, C4, and levels of immunoglobulins G, A, and M were also measured to evaluate vitamin B<sub>12<\/sub> effect on immunity. Values obtained before treatment with cyanocobalamin were compared with those found during peak reticulocyte count. <i>Results:<\/i> In vitamin B<sub>12<\/sub>-deficient patients, absolute numbers of CD4+ and especially CD8+ lymphocytes were found to be decreased; CD4\/CD8 ratio increased, and NK cell activity was depressed. After cyanocobalamin treatment, absolute numbers and percentage of lymphocyte subgroups were elevated. Increased CD4\/CD8 ratio and depressed NK cell activity were restored and levels of C3, C4, and immunoglobulins were elevated. <i>Conclusion:<\/i> These findings suggest that vitamin B<sub>12<\/sub> has important immunomodulatory effects on cellular immunity, and abnormalities in the immune system in pernicious anemia are restored by vitamin B<sub>12<\/sub> replacement therapy.<\/jats:p>","DOI":"10.1159\/000112967","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T11:10:26Z","timestamp":1203505826000},"page":"131-135","source":"Crossref","is-referenced-by-count":46,"title":["Effects of Cyanocobalamin on Immunity in Patients with Pernicious Anemia"],"prefix":"10.1159","volume":"17","author":[{"given":"Mehmet Ali","family":"Erkurt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismet","family":"Aydogdu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Dikilita\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Kuku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emin","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihayet","family":"Bayraktar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur","family":"Ozhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Ozkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"S\u00f6nmez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.38.5.582"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fajh.2830240214"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2169%2Finternalmedicine.31.125"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2249.1999.00870.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00916893"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-2427%2896%2905560-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0609.1985.tb01725.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01296707"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.1997.d01-2075.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819930201%2971%3A3%3C745%3A%3AAID-CNCR2820710316%3E3.0.CO%3B2-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1024%2F0300-9831.70.4.167"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:34:22Z","timestamp":1745462062000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000112967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000112967","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}