{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:27:15Z","timestamp":1782156435345,"version":"3.54.5"},"reference-count":12,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Peritonitis is one of the complications of peritoneal dialysis. We demonstrate the systemic and intraperitoneal anti-inflammatory action of sulodexide given systemically. &lt;i&gt;Methods:&lt;\/i&gt; Dialysis was performed in male Wistar rats with acute peritonitis induced by addition of endotoxin to the fluid. Sulodexide (10 mg\/kg b.w.) was used acutely as supplement to the dialysis fluid or chronically, during 7 days preceding the study by intramuscular (IM) injection. &lt;i&gt;Results:&lt;\/i&gt; In rats given IM sulodexide the dialysate cell count was lower by 45% (p &lt; 0.001) versus untreated rats with peritonitis. Dialysate elastase activity in IM sulodexide-treated rats was lower by 22% (p &lt; 0.05) compared to peritonitis. In rats treated with IM sulodexide the increase of plasma tumor necrosis factor-\u03b1 was reduced by 53% (p &lt; 0.002). Pretreatment with IM sulodexide reduced transperitoneal loss of total protein and albumin during peritonitis by 26% (p &lt; 0.002) and by 16% (p &lt; 0.05), respectively. &lt;i&gt;Conclusion:&lt;\/i&gt; Sulodexide given systemically reduces the intraperitoneal and vascular inflammatory response during acute peritonitis in rats.<\/jats:p>","DOI":"10.1159\/000113011","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T14:33:25Z","timestamp":1200062005000},"page":"510-514","source":"Crossref","is-referenced-by-count":19,"title":["Anti-Inflammatory Effect of Sulodexide during Acute Peritonitis in Rats"],"prefix":"10.1159","volume":"25","author":[{"given":"Jacek","family":"Karo\u0144","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Po\u0142ubinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur A.","family":"Antoniewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Sumi\u0144ska-Jasi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Br\u0119borowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,1,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-9150%2890%2990071-P"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.104.510016"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1124%2Fjpet.104.075283"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1992.288"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2165%2F00024677-200605040-00002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2899%2970264-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2895%2991506-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F17.suppl_11.28"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080%2F08860220600583625"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00946.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000085289"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.121.5_suppl.156S"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:34:54Z","timestamp":1745462094000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000113011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":12,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2008,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000113011","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}