{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:29:27Z","timestamp":1773235767072,"version":"3.50.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; GH may improve phosphate balance and height in X-linked hypophosphatemic rickets (XLH). This study evaluated the impact of exclusive rhGH therapy on phosphate homeostasis and growth. &lt;i&gt;Methods:&lt;\/i&gt; Ten children (median age 12.2 years) with XLH were included in a 12-month trial with GH. Conventional treatment was discontinued 1 month prior GH (0.033 mg\/kg\/day); 1\u03b1-hydroxyvitamin D was added at 6 months and oral phosphate at 12 months, when GH was discontinued. Patients were followed 1\u20133 monthly until 18 months for clinical, biochemical and radiographic parameters. &lt;i&gt;Results:&lt;\/i&gt; Serum phosphate Z-score increased significantly from baseline at 6 months (p = 0.005) and 9 months (p = 0.009) but returned to baseline by 12 months. Serum 1,25-dihydroxyvitamin D also increased significantly. Parathyroid function normalized. The median height Z-score was \u20132.2 (\u20132.7 to +0.4) at GH onset and \u20131.7 (\u20132.3 to +0.3) at 12 months. One patient showed a significant increase in radiographic rickets activity and 3 patients aggravation of lower limb deformity; the others showed no changes or improvement in these parameters. &lt;i&gt;Conclusions:&lt;\/i&gt; GH treatment improved serum phosphate and 1,25-dihydroxyvitamin D, normalized parathyroid function and improved longitudinal growth in XLH. It may however aggravate pre-existing skeletal deformities.<\/jats:p>","DOI":"10.1159\/000113021","type":"journal-article","created":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T13:35:52Z","timestamp":1200663352000},"page":"212-220","source":"Crossref","is-referenced-by-count":16,"title":["Metabolic Control and Growth during Exclusive Growth Hormone Treatment in X-Linked Hypophosphatemic Rickets"],"prefix":"10.1159","volume":"69","author":[{"given":"Outi","family":"M\u00e4kitie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanna","family":"Toiviainen-Salo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eino","family":"Marttinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkka","family":"Kaitila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Sochett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkka","family":"Sipil\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2885%2980068-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1095-130"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.8.3889"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.2.494"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.2005-0019"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM197209072871003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI111900"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199112263252604"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.76.4.839"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-030036"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1507%2Fendocrj.47.163"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2001.108955"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000077401"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.2003.01685.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0026-0495%2864%2990072-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0005-2736%2880%2990378-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.1.81"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2895%2970070-6"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02079060"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.100.5.879"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1990.tb11503.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.12.4702"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0303-7207%2800%2900310-5"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.1996.740561.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004670050340"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1677%2Fjoe.1.05947"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.01874"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:34:58Z","timestamp":1745462098000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000113021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000113021","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}