{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:57:42Z","timestamp":1745470662003,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background\/Aim:<\/i> The insulin tolerance test (ITT) remains the gold standard for evaluating the pituitary function, but has potential risks when hypoglycaemia is induced. There are scarce data using short-acting insulin analogs for ITTs. This pilot study compares the effects of insulin lispro (LPI) with regular insulin (RGI) during an ITT. <i>Methods:<\/i> Patients with suspected hypopituitarism (n = 103) randomly received either LPI (n = 51) or RGI (n = 52). <i>Results:<\/i> All patients reported signs and symptoms when hypoglycaemia was induced. In the LPI group, hypoglycaemia occurred sooner (23.6 \u00b1 1.6 vs. 28.3 \u00b1 1.4 min, p < 0.05), and duration of hypoglycaemia (25.0 \u00b1 1.7 vs. 31.9 \u00b1 1.9 min, p < 0.05) and time for blood glucose levels to return to a \u2018safe\u2019 level (>3.3 mmol\/l; 56.5 \u00b1 2.3 vs. 76.0 \u00b1 2.1 min, p < 0.001) were shorter as compared with the RGI group. No differences in peak growth hormone and cortisol levels were observed between the two groups. <i>Conclusions:<\/i> Our data suggest that despite inducing similar symptomatology, LPI exerted a quicker onset and a shorter duration of hypoglycaemia as compared with RGI. Thus, using LPI might reduce the potential risks associated with an ITT by shortening the hypoglycaemic phase of the test.<\/jats:p>","DOI":"10.1159\/000113024","type":"journal-article","created":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T13:35:52Z","timestamp":1200663352000},"page":"233-239","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Pituitary Function with Insulin Tolerance (Hypoglycaemia) Testing: Are There Any Differences Using Insulin Lispro Compared to Regular Insulin?"],"prefix":"10.1159","volume":"69","author":[{"given":"Kevin C.J.","family":"Yuen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie B.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon A.","family":"Rhoads","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.11.3990"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.2.379"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.7.2350"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-021994"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.79.4.923"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2006.02436.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1994.tb03793.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000079539"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199610173351607"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.1998.00362.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1470041"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2894%2991998-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.01992"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-9136%28199807%2915%3A7%3C539%3A%3AAID-DIA668%3E3.0.CO%3B2-S"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.5.2067"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0026-0495%2886%2990245-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9343%2802%2901176-2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.49.6.999"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001250051402"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0149-2918%2898%2980040-4"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI6609"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M313201200"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1042%2F0264-6021%3A3390675"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00405001"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M007988200"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI105358"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-978997"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-9136%28199711%2914%3A11%3C929%3A%3AAID-DIA477%3E3.0.CO%3B2-4"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiacare.21.1.93"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-9136%28199703%2914%3A3%3C248%3A%3AAID-DIA337%3E3.0.CO%3B2-0"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:34:59Z","timestamp":1745462099000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000113024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000113024","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2008]]}}}