{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:08:18Z","timestamp":1778720898184,"version":"3.51.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Brain \u03b2-amyloid (A\u03b2) deposition is an extremely common accompaniment of aging in humans and many other mammalian species. We hypothesized that normal physiological changes of aging cause A\u03b2 deposition. &lt;i&gt;Objective:&lt;\/i&gt; Three normal physiological aging changes were induced in young adult rabbits to determine their effects on brain A\u03b2 concentrations and deposition. The three changes were cortical cholinergic deafferentation, hypercholesterolemia and estrogen deprivation. &lt;i&gt;Methods:&lt;\/i&gt; Cortical cholinergic deafferentation was achieved through intracerebroventricular immunotoxin injection. Hypercholesterolemia was induced with a 2% cholesterol diet. Estrogen deprivation was modeled with ovariectomy. &lt;i&gt;Results:&lt;\/i&gt; Cortical cholinergic deafferentation resulted in an 8-fold increase in cortical A\u03b2&lt;sub&gt;42&lt;\/sub&gt; concentrations and cerebovascular A\u03b2 deposition. Hypercholesterolemia increased cortical A\u03b2&lt;sub&gt;42&lt;\/sub&gt; 4.6-fold while ovariectomy increased cortical A\u03b2&lt;sub&gt;42&lt;\/sub&gt; 1.6-fold. &lt;i&gt;Conclusion:&lt;\/i&gt; At least three physiological changes of normal aging may underlie age-related brain A\u03b2 accumulation and Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1159\/000113685","type":"journal-article","created":{"date-parts":[[2008,3,5]],"date-time":"2008-03-05T13:10:47Z","timestamp":1204722647000},"page":"143-145","source":"Crossref","is-referenced-by-count":25,"title":["Physiologic Origins of Age-Related \u03b2-Amyloid Deposition"],"prefix":"10.1159","volume":"5","author":[{"given":"Thomas G.","family":"Beach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0197-4580%2893%2990096-T"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fcercor%2F4.2.138"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2800%2900916-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.2000.tb06388.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0197-4580%2892%2990113-C"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004010050595"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410230206"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2887%2990272-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.8346443"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.322.7300.1447"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000026149"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00702-002-0809-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1006%2Fexnr.1994.1044"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0531-5565%2800%2900157-1"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113685","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:51:07Z","timestamp":1745459467000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000113685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":14,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000113685","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}