{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:20:04Z","timestamp":1768814404091,"version":"3.49.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Fibers containing galanin (GAL) enlarge and hyperinnervate cholinergic basal forebrain (CBF) nucleus basalis (NB) neurons in late-stage Alzheimer\u2019s disease (AD), yet the physiological consequences of this phenomenon are unclear. &lt;i&gt;Objective:&lt;\/i&gt; To determine whether GAL hyperinnervation of cholinergic NB neurons modulates the expression of genes critical to cholinergic transmission [e.g. acetylcholine (ACh) metabolism and ACh receptors] in AD. &lt;i&gt;Methods:&lt;\/i&gt; Single-cell gene expression profiling was used to compare cholinergic mRNA levels in non-GAL-hyperinnervated NB neurons in tissue autopsied from cases classified as having no cognitive impairment (NCI) or late-stage AD (AD\/GAL\u2013) and in GAL-hyperinnervated (AD\/GAL+) NB neurons from the same AD subjects. &lt;i&gt;Results:&lt;\/i&gt; AD\/GAL+ cells displayed a significant upregulation in choline acetyltransferase (ChAT) mRNA expression compared to NCI and AD\/GAL\u2013 cells. &lt;i&gt;Conclusion:&lt;\/i&gt; GAL fiber hyperinnervation of cholinergic NB neurons upregulates the expression of ChAT, the synthetic enzyme for ACh, suggesting that GAL regulates the cholinergic tone of CBF neurons in AD.<\/jats:p>","DOI":"10.1159\/000113710","type":"journal-article","created":{"date-parts":[[2008,3,5]],"date-time":"2008-03-05T13:10:47Z","timestamp":1204722647000},"page":"228-231","source":"Crossref","is-referenced-by-count":31,"title":["Galanin Hyperinnervation Upregulates Choline Acetyltransferase Expression in Cholinergic Basal Forebrain Neurons in Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"5","author":[{"given":"Scott E.","family":"Counts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoli","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen D.","family":"Ginsberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliott J.","family":"Mufson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.84.20.7339"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1006%2Fexnr.2000.7397"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2876%2991936-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1750-3639.1997.tb01058.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fcne.902730409"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000107329"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000090906"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1020952704398"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fcne.902850204"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.2000.741185.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.2006.03764.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.labinvest.3700005"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nbd.2005.08.016"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1124%2Fmi.3.3.137"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:51:30Z","timestamp":1745459490000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000113710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":14,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000113710","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}