{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:28:42Z","timestamp":1789723722655,"version":"4.0.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Tetracyclines may be useful in preventing pathological vascular remodeling, thus decreasing the risk of spontaneous hemorrhage from brain vascular malformations. &lt;i&gt;Methods:&lt;\/i&gt; Arteriovenous malformation (AVM) and intracranial aneurysm patients undergoing noninvasive management were treated with minocycline or doxycycline (200 mg\/day) up to 2 years in a prospective open-label safety pilot trial. The primary outcome was to compare dose-limiting intolerance, defined as treatment-related dose reduction or withdrawal between the agents.&lt;i&gt;Results:&lt;\/i&gt; Twenty-six patients with AVMs (n = 12) or aneurysms (n = 14) were recruited. Adverse event rates were similar to other reported trials of these agents; 4 of 13 (31%) minocycline and 3 of 13 (23%) doxycycline patients had dose-limiting intolerance (hazard ratio = 3.1, 95% CI = 0.52\u201318.11, log rank p = 0.70). &lt;i&gt;Conclusions:&lt;\/i&gt; It is feasible to propose a long-term trial to assess the potential benefit of tetracycline therapy to decrease hemorrhagic risk in brain vascular malformations.<\/jats:p>","DOI":"10.1159\/000113733","type":"journal-article","created":{"date-parts":[[2008,1,28]],"date-time":"2008-01-28T07:48:52Z","timestamp":1201506532000},"page":"157-163","source":"Crossref","is-referenced-by-count":53,"title":["Feasibility of Minocycline and Doxycycline Use as Potential Vasculostatic Therapy for Brain Vascular Malformations: Pilot Study of Adverse Events and Tolerance"],"prefix":"10.1159","volume":"25","author":[{"given":"Tim","family":"Frenzel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanhung Z.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Quinnine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Lawton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Joseph","family":"Guglielmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"McCulloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,1,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.96.23.13496"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2Fhs0302.104542"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.10553"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawf133"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00006123-200106000-00051"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0741-5214%2800%2990163-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000038098.04291.F6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067%2Fmva.2002.125018"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2377-5-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2741%2F2037"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00006123-199911000-00024"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrc905"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000201252.57661.e1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2165%2F00002018-200022030-00007"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinthera.2005.09.005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1517%2F13543784.9.9.2159"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0049-0172%2899%2980004-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.159.5.493"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000130988.44824.29"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000210524.68507.87"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2803%2913860-3"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:51:47Z","timestamp":1745459507000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000113733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":21,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2008,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000113733","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}