{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:10:10Z","timestamp":1745460610920,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Genomics"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Objective:<\/i> To describe the psychological reaction to information about diagnostic genetic testing for \u03b1-1 antitrypsin deficiency (Alpha-1) and cystic fibrosis (CF) in chronic obstructive pulmonary disease and\/or bronchiectasis patients who were tested but did not know the results. <i>Methods:<\/i> One hundred and three adults took the State-Trait Anxiety Inventory before and after a standardized educational intervention and responded to a questionnaire. <i>Results:<\/i>Information about the limitations, risks and benefits of Alpha-1 and CF testing did not raise mean anxiety levels. Mean anxiety was slightly lower after the educational intervention than at baseline (mean pretest score 35.0, posttest score 33.7; p < 0.05). Participants whose physician preinformed them of genetic testing had slightly higher mean anxiety than other participants, both before and after the intervention, but scores were comparable to those in a normative sample of general medical and surgical patients. <i>Conclusions:<\/i> Disclosure of information regarding Alpha-1 and CF testing appears to be potentially acceptable to patients and unlikely to prevent clinicians from conducting useful diagnostic procedures. This study is a step in alleviating concerns about raising issues related to genetic testing for Alpha-1 and CF in chronic obstructive pulmonary disease patients during the informed consent process.<\/jats:p>","DOI":"10.1159\/000113875","type":"journal-article","created":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T20:47:51Z","timestamp":1206737271000},"page":"135-140","source":"Crossref","is-referenced-by-count":1,"title":["Anxiety Related to Genetic Testing for Alpha-1 Antitrypsin Deficiency and Cystic Fibrosis in COPD and\/or Bronchiectasis Patients"],"prefix":"10.1159","volume":"11","author":[{"given":"Marilyn E.","family":"Coors","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold H.","family":"Levinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwen A.","family":"Huitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fjme.26.4.261"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1089%2F109065702761403360"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fjme.29.2.70"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.genom.5.061903.180029"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4065%2F80.1.63"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200320113"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1089%2F109065701753145556"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.39.9.689"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.07.102"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1089%2F10906570050501489"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.a.30255"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-0275"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2Fnbt1205-1479"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2307%2F797066"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%2819980217%2975%3A5%3C461%3A%3AAID-AJMG3%3E3.0.CO%3B2-Q"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.socscimed.2003.11.025"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2005-869536"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1037%2F0278-6133.16.1.51"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.10736"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2892%2990477-K"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.31.5.364"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10897-005-4065-z"}],"container-title":["Public Health Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:53:42Z","timestamp":1745459622000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000113875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000113875","archive":["Portico"],"relation":{},"ISSN":["1662-4246","1662-8063"],"issn-type":[{"type":"print","value":"1662-4246"},{"type":"electronic","value":"1662-8063"}],"subject":[],"published":{"date-parts":[[2008]]}}}