{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:25:38Z","timestamp":1771017938396,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>Adalimumab is a fully humanized recombinant anti-tumour-necrosis-factor (TNF-\u03b1) monoclonal antibody which has been approved for rheumatoid arthritis, active ankylosing spondylitis, psoriatic arthritis and Crohn\u2019s disease. We report a case of alopecia areata (AA) universalis occurring 6 months after administration of adalimumab monotherapy in a patient with a long-standing history of psoriatic arthritis and psoriasis. The diagnosis was confirmed by a scalp biopsy which showed a peribulbar infiltrate of both CD4+ and CD8+ T cells, CD1a+ dendritic cells as well as CD68+ and CD163+ macrophages. In addition, immunofluorescence staining for TNF-\u03b1 was found in the mononuclear cell infiltrate. This case suggests a complex role of TNF-\u03b1 in the induction of AA.<\/jats:p>","DOI":"10.1159\/000113945","type":"journal-article","created":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T11:02:04Z","timestamp":1201690924000},"page":"320-323","source":"Crossref","is-referenced-by-count":52,"title":["Alopecia Areata Universalis Elicited during Treatment with Adalimumab"],"prefix":"10.1159","volume":"216","author":[{"given":"Nedzmidin","family":"Pelivani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akmal S.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lasse R.","family":"Braathen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Hunger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Yawalkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2006.01058.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2006.08.025"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.143.7.900"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1996.d01-1099.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2005.03.039"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.141.6.759"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.140.8.1012-a"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.142.12.1654"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00002281-200307000-00003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.semarthrit.2005.01.002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.143.2.223"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.drudis.2006.11.013"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4065%2F70.7.628"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/113945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:54:27Z","timestamp":1745459667000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000113945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000113945","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}