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Being refractory to steroid and anti-lymphocyte serum, the patient received allogeneic stem cell transplantation, achieving complete remission. We discuss here the potential mechanisms by which phenobarbital and other anti-epileptic drugs can cause aplastic anemia and review the literature for previous case reports and epidemiological studies.<\/jats:p>","DOI":"10.1159\/000114096","type":"journal-article","created":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T11:02:04Z","timestamp":1201690924000},"page":"18-21","source":"Crossref","is-referenced-by-count":11,"title":["Phenobarbital-Associated Bone Marrow Aplasia: A Case Report and Review of the Literature"],"prefix":"10.1159","volume":"119","author":[{"given":"Daniele","family":"Focosi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Eric","family":"Kast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Benedetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Papineschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Galimberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Petrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199606133342407"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM196907032810102"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109%2F15563658008989927"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%2819970414%2969%3A4%3C388%3A%3AAID-AJMG10%3E3.0.CO%3B2-J"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-9681%2887%2990073-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0895-4356%2888%2990069-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fajh.20954"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.1.6075.1500"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1528-1167.2006.00596.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.1.5479.108-d"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1526-4610.1969.hed0901092.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0387-7604%2897%2900580-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2004-06-2444"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.229.3.314"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00451918"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1532-5415.2002.50083.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0920-1211%2801%2900320-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2165%2F00003495-199345060-00008"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM195706272562607"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.1.5382.562-e"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.1.5744.349-c"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F0887-8994%2894%2990093-0"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1983.tb09845.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-510X%2896%2900256-0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2FS0387-7604%2802%2900004-9"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1528-1167.2005.00264.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097%2F00043426-199021000-00016"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/114096","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/114096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:55:55Z","timestamp":1745459755000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000114096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000114096","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}