{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:49:33Z","timestamp":1791236973138,"version":"4.1.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> Idiopathic pulmonary fibrosis (IPF) is a disease with very high mortality. <i>Objective: <\/i>We sought to characterize serial changes in pulmonary artery pressures (PAP) in patients with advanced IPF who survive to transplant. <i>Methods:<\/i> Retrospective analysis of IPF patients comparing mean PAP at the time of initial evaluation for transplan- tation (mPAP<sub>baseline<\/sub>) with mPAP at the time of transplant (mPAP<sub>follow-up<\/sub>). The measurements were correlated with New York Heart Association (NYHA) functional class and oxygen requirements. <i>Results:<\/i> The final cohort consisted of 44 patients with serial right heart catheterization data. The mean mPAP<sub>baseline<\/sub> and mPAP<sub>follow-up<\/sub> were 22.5 and 32.7 mm Hg, respectively. 38.6% (17\/44) of the patients had pulmonary hypertension (PH) at baseline. The majority of the non-PH patients developed PH during the serial time interval with a subsequent incidence of 77.8%. At the time of transplant, 86.4% of the patients had PH. There was a significant association between transplant NYHA class, severity of PH and oxygen requirements. Transplant NYHA class IV patients had a higher rate of mPAP change. The severity of PH at the time of transplant did not affect transplant outcomes. <i>Conclusion:<\/i> PH is common and progressive in patients with advanced IPF who are transplant candidates. Serial change and severity of PAP elevations have a significant association with oxygen requirements and functional status, but not transplant outcomes. Whether or not progressive PH has a significant impact on outcomes without transplantation requires further study.<\/jats:p>","DOI":"10.1159\/000114246","type":"journal-article","created":{"date-parts":[[2008,1,25]],"date-time":"2008-01-25T08:26:27Z","timestamp":1201249587000},"page":"288-294","source":"Crossref","is-referenced-by-count":196,"title":["Serial Development of Pulmonary Hypertension in Patients with Idiopathic Pulmonary Fibrosis"],"prefix":"10.1159","volume":"76","author":[{"given":"Steven D.","family":"Nathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana A.","family":"Shlobin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzad","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niv","family":"Ad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200210-1245OC"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200209-1112OC"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200211-1311OC"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.127.1.171"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000064006"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.06-2485"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1309%2F0B06Y93EGE6TQ36Y"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.123.5.1758"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200308-1111OC"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200308-1151OC"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200202-135OC"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200312-1670OC"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200409-1164OC"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.2003.009860"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.128.6_suppl.601S"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199602013340504"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200307-957OC"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200308-1142OC"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200210-1130OC"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2911024-5"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/114246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/114246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:57:37Z","timestamp":1745459857000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000114246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000114246","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}