{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:56:04Z","timestamp":1745470564200,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Objective:<\/i> Hydroxyethyl starch (HES) solutions are widely used for fluid resuscitation. We studied the effects of HES on endothelium-dependent relaxation (EDR), especially on the endothelium-derived hyperpolarizing factor (EDHF). <i>Methods:<\/i> Four-millimeter-long rings of fresh porcine coronary arteries from the local slaughterhouse were consecutively tested with or without HES (6 mg\/ml). Indomethacin (10 \u00b5mol\/l) was added in all measurements to eliminate prostacyclin effects. Prostaglandin F2\u03b1 (10 \u00b5mol\/l) was used for contraction and bradykinin (10<sup>\u201310<\/sup> to 10<sup>\u20135<\/sup> mol\/l) for inducing EDR, which was calculated in percentage of the precontraction. After blocking all nitric oxide formation by N-nitro-<i>L<\/i>-arginine (300 \u00b5mol\/l), the experiments were repeated to assess the EDHF-mediated relaxation response to bradykinin. <i>Results:<\/i> HES 6 mg\/ml induced a significant (p < 0.01) reduction in EDR (n = 8). After incubation with HES and nitric oxide blockage with N-nitro-<i>L<\/i>-arginine, the relaxation response was reduced especially for the bradykinin concentrations of 10<sup>\u20136<\/sup> mol\/l (p < 0.05) and 10<sup>\u20135<\/sup> mol\/l (p < 0.01). <i>Conclusion:<\/i> For the clinically relevant concentration of 6 mg\/ml HES, a significant reduction in EDR and the EDHF can be found in epicardial coronary arteries of the pig.<\/jats:p>","DOI":"10.1159\/000114448","type":"journal-article","created":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T11:02:04Z","timestamp":1201690924000},"page":"241-245","source":"Crossref","is-referenced-by-count":2,"title":["Hydroxyethyl Starch Inhibits Endothelium-Derived Relaxation in Porcine Coronary Arteries"],"prefix":"10.1159","volume":"81","author":[{"given":"Oguzhan","family":"Dagtekin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Krep","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen Hartmut","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000217611.81085.c5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00227892"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1681.1998.tb02163.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F01.shk.0000180625.53800.63"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000064005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F00000542-200510000-00014"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejcts.2005.09.015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000127896"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01716806"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2893%2992345-T"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2896%2907588-5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2904211-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2004.06272.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI116907"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02425053"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejvs.2005.04.046"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1213%2F01.ane.0000258224.44806.dd"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/114448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/114448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:59:37Z","timestamp":1745459977000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000114448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000114448","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2008]]}}}