{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:10:25Z","timestamp":1790017825518,"version":"4.0.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> Cases of allergy to <i>Cannabis sativa<\/i> have occasionally been reported, but both the allergenic profile and eventual cross-reactivity pattern remain unknown. <i>Objective:<\/i> To analyze the allergenic profile of a population of patients from Spain sensitized to <i>C. sativa<\/i> and to characterize the <i>C. sativa <\/i>leaf extract. <i>Methods:<\/i> A total of 32 subjects were enrolled in the study: group A, 10 individuals sensitized to tomato, reporting reactions by contact or inhalation to <i>Cannabis<\/i>; group B, 14 individuals sensitized to tomato, without reactions to <i>Cannabis<\/i>; group C, 8 individuals not sensitized to tomato and without reactions to <i>Cannabis<\/i>. Sensitivity to <i>Cannabis<\/i>, tomato and peach peel, <i>Platanus hybrida<\/i> and <i>Artemisia vulgaris<\/i> pollen extracts was measured by skin tests and specific IgE. Individual immunoblots and inhibition experiments with a pool of sera were conducted. <i>Results:<\/i> All tomato-sensitized subjects (and 1 negative) had positive skin tests to <i>C. sativa <\/i>leaves and hashish. Specific IgE to <i>C. sativa <\/i>and peach peel was more common than to tomato. Immunoblot experiments showed 2 prominent bands of 10 and 14 kDa and 2 weakly recognized bands of 30 and 45 kDa. Tomato, peach and <i>A. vulgaris<\/i> extracts inhibited most of the bands present in <i>C. sativa<\/i>. <i>P. hybrida<\/i> inhibited only the high-molecular-weight bands. <i>Conclusion:<\/i> Sensitization to <i>C. sativa <\/i>with or without symptoms is frequent among patients in Spain sensitized to tomato. <i>C. sativa<\/i> leaves are a potential allergenic source and their allergens may cross-react with other allergenic sources from plants (fruit peels and pollen).<\/jats:p>","DOI":"10.1159\/000115887","type":"journal-article","created":{"date-parts":[[2008,2,11]],"date-time":"2008-02-11T09:27:50Z","timestamp":1202722070000},"page":"195-202","source":"Crossref","is-referenced-by-count":38,"title":["Sensitization and Allergy to <i>Cannabis sativa<\/i> Leaves in a Population of Tomato <i>(Lycopersicon esculentum)<\/i>-Sensitized Patients"],"prefix":"10.1159","volume":"146","author":[{"given":"Carlos Hernando","family":"de Larramendi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jer\u00f3nimo","family":"Carn\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Garc\u00eda-Abujeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garc\u00eda-Endrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mu\u00f1oz-Palomino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel Julio","family":"Huertas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Fern\u00e1ndez-Caldas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1996.tb00068.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0105-1873.2006.0560h.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0736-4679%2899%2900209-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2962473-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS1352-2310%2897%2900161-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2003.1591"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1991.tb00638.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fajim.4700260109"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2F227680a0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.167.3.221"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1124%2Fjpet.104.068635"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1142265"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0379-0738%2898%2900152-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2002.125830"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.02.031"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2007.02653.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2006.05.012"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/115887","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/115887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:14:36Z","timestamp":1745460876000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000115887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000115887","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}