{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:17:59Z","timestamp":1765959479796,"version":"3.40.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> Preterm infants often present with recurrent episodes of hypoxemia after mechanical ventilation. <i>Objective:<\/i> To evaluate the role of abdominal muscle activity and central apnea on the frequency and severity of hypoxemia episodes (HEs) in preterm infants with a history of mechanical ventilation. <i>Methods:<\/i> Continuous recordings of arterial oxygen saturation (SpO<sub>2<\/sub>), gastric pressure, respiratory inductance plethysmography and abdominal surface electromyography were obtained during 4 h from spontaneously breathing preterm infants who had recently been extubated and presented with frequent HEs. <i>Results:<\/i> Ten infants (gestational age 26.4 \u00b1 1.1 weeks, body weight 816 \u00b1 128 g, age 44 \u00b1 21 days, FiO<sub>2<\/sub> 0.31 \u00b1 0.09, mechanically ventilated for 33 \u00b1 37 days) were studied 12 \u00b1 7 (mean \u00b1 SD) days after extubation. These infants presented with 10.2 \u00b1 9.3 HEs\/h (SpO<sub>2<\/sub> <88%, \u226710 s). Of these, 8.2 \u00b1 6.2 HEs\/h were associated with abdominal muscle contraction while only 2.0 \u00b1 4.5 HEs\/h were associated with \u226710 s apnea (p < 0.05). Of the more severe HEs (SpO<sub>2<\/sub> <75%, \u226710 s), 2.7 \u00b1 3.1 HEs\/h were associated with abdominal contraction and only 0.7 \u00b1 2.1 HEs\/h with apnea (p < 0.05). Resting lung volume decreased by 69 \u00b1 16% of tidal volume in HEs associated with abdominal contraction. <i>Conclusions:<\/i> In this group of premature infants who presented with frequent HEs after mechanical ventilation, most HEs were associated with abdominal muscles contraction and a loss in lung volume. These findings provide an alternate mechanism to explain these episodes in spontaneously breathing preterm infants with a history of mechanical ventilation.<\/jats:p>","DOI":"10.1159\/000116634","type":"journal-article","created":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T15:20:14Z","timestamp":1203088814000},"page":"100-104","source":"Crossref","is-referenced-by-count":35,"title":["Mechanisms of Hypoxemia Episodes in Spontaneously Breathing Preterm Infants after Mechanical Ventilation"],"prefix":"10.1159","volume":"94","author":[{"given":"Cristian","family":"Esquer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Claure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"D\u2019Ugard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Bancalari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2895%2970171-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000102056"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2898%2970481-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00442697"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2002.127277"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2897%2970242-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.siny.2003.11.009"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/116634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/116634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:22:05Z","timestamp":1745461325000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000116634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":7,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000116634","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2008]]}}}