{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:35:31Z","timestamp":1791938131330,"version":"4.3.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; In asphyxiated neonates, abnormal proinflammatory cytokine\/chemokine production may be induced. High-mobility group box 1 (HMGB-1) protein is a new type of proinflammatory cytokine that induces abnormal inflammatory responses involving proinflammatory cytokine production. However, the physiological significance of HMGB-1 in asphyxia is poorly understood. &lt;i&gt;Objectives:&lt;\/i&gt; We aimed to evaluate whether serum HMGB-1 levels were changed in asphyxia by measuring the serum concentration of HMGB-1 in both asphyxiated and normally delivered neonates at birth. &lt;i&gt;Methods:&lt;\/i&gt; Using enzyme-linked immunosorbent assay, we measured the concentration of HMGB-1 in sera obtained from 53 asphyxiated neonates and 32 normally delivered neonates immediately after birth. &lt;i&gt;Results:&lt;\/i&gt; The serum concentrations of HMGB-1 in asphyxiated neonates were significantly higher than those in normally delivered neonates without asphyxia (p = 0.033). &lt;i&gt;Conclusion:&lt;\/i&gt; We suggest that the elevation of HMGB-1 might be associated with abnormal inflammatory responses involving the excessive production of proinflammatory cytokines in neonates with asphyxia.<\/jats:p>","DOI":"10.1159\/000116635","type":"journal-article","created":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T15:20:14Z","timestamp":1203088814000},"page":"105-109","source":"Crossref","is-referenced-by-count":20,"title":["Elevation of High-Mobility Group Box 1 Concentration in Asphyxiated 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