{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:01:32Z","timestamp":1762297292411,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Objectives:<\/i> To evaluate the rate of chromosome abnormalities in cases of uni- and bilateral choroid plexus cysts (CPCs). <i>Methods:<\/i> A total of 10,875 ultrasound (US) examinations were performed in the second trimester, and 435 cases with CPC (4%) were found. After genetic counseling, 45 patients decided not to undergo karyotyping. The authors performed a chromosome analysis in 390 cases of CPCs. <i>Results:<\/i> The total risk of chromosome abnormalities was 3.59% (n = 14) and risk of trisomies was 2.05% (n = 8). Trisomy 18 was found in 6 cases (1.54%), trisomy 21 in 1 case (0.26%), and trisomy 9 in 1 case (0.26%). The risk of 45,X karyotype was 0.77% (n = 3). One case of 47,XXY karyotype and 2 cases with other chromosome abnormalities were found. In 212 unilateral cases there were 7 with chromosome abnormalities (3.3%). In 178 bilateral cases there were 7 with abnormal karyotypes (3.93%). The CPC was associated with additional fetal US anomalies (with or without polyhydramnios\/oligohydramnios) in 112 cases; chromosome abnormalities were detected in 4 cases (3.57%). 66 cases were associated with polyhydramnios\/oligohydramnios but not with other fetal US anomalies; 3 cases of abnormal karyotypes were found (4.55%). The CPC was isolated in 212 cases and 7 cases were associated with chromosome disorders (3.3%). <i>Conclusions:<\/i> US plays an important role in prenatal diagnostics. Further genetic counseling is recommended in cases with CPCs.<\/jats:p>","DOI":"10.1159\/000116739","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T11:10:26Z","timestamp":1203505826000},"page":"185-191","source":"Crossref","is-referenced-by-count":27,"title":["Risk of Chromosome Abnormalities in the Presence of Bilateral or Unilateral Choroid Plexus Cysts"],"prefix":"10.1159","volume":"23","author":[{"given":"Art\u00far","family":"Beke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emese","family":"Barakonyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zor\u00e1n","family":"Belics","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef G.","family":"Jo\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1kos","family":"Csaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Papp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ern\u0151","family":"T\u00f3th-P\u00e1l","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Papp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,2,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fbeog.2000.0099"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1970141205"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1970140804"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199611%2916%3A11%3C983%3A%3AAID-PD975%3E3.0.CO%3B2-C"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0223%28200008%2920%3A8%3C657%3A%3AAID-PD866%3E3.0.CO%3B2-S"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.1970040207"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2886%2990824-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1994.04060448.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0028-2243%2894%2902011-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1997.10030171.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0929-8266%2898%2900052-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1998.12060391.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2800%2970356-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijgo.2003.08.016"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/116739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/116739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:23:10Z","timestamp":1745461390000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000116739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000116739","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2008]]}}}