{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T06:54:49Z","timestamp":1760424889682,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,2,14]],"date-time":"2008-02-14T00:00:00Z","timestamp":1202947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,2,14]],"date-time":"2008-02-14T00:00:00Z","timestamp":1202947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Dysregulation of integrins is a feature of tissue remodeling in autosomal-dominant polycystic kidney disease (ADPKD). The alpha 8 beta 1 integrin (\u03b18\u03b21) affects kidney development and the susceptibility to renal injury in mice. We investigated whether the \u2013414 T\/C polymorphism in the promoter region of the alpha 8 integrin chain gene (ITGA8) is associated with the progression of renal disease in ADPKD. &lt;i&gt;Methods:&lt;\/i&gt; Genotyping for the \u2013414 T\/C polymorphism was performed by allelic separation using RT-PCR in 294 patients with ADPKD. Alpha 8 integrin expression was detected by RT-PCR and immunohistochemistry. &lt;i&gt;Results:&lt;\/i&gt; 41% of the study population reached end stage renal disease at a mean age of 51 \u00b1 12 years. The frequency of the \u2013414 C allele was 0.194 in ADPKD. C allele carriers (CC and TC genotypes) were compared with patients homozygous for the T allele (TT genotype). Kaplan-Meier analysis revealed that end-stage renal failure occurred at a significantly younger age in TT homozygotes (median age, 47 years; 95% CI, 46\u201349 years) than in C allele carriers (median age, 51 years; 95% CI, 49\u201353 years; p = 0.046 by the log-rank test). When parameters of ADPKD patients were compared between genotype by analysis of variance, only age at onset of end-stage renal failure was significantly different (p = 0.026) whereas age at onset of hypertension, body surface area, 24-hour systolic and diastolic blood pressure did not differ. In kidneys of ADPKD, expression of alpha 8 integrin is increased and found de novo in cystic epithelia. &lt;i&gt;Conclusion:&lt;\/i&gt; A polymorphism of the ITGA8 promoter modifies the progression of renal failure in ADPKD.<\/jats:p>","DOI":"10.1159\/000116887","type":"journal-article","created":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T11:19:14Z","timestamp":1202901554000},"page":"c169-c175","source":"Crossref","is-referenced-by-count":19,"title":["A Promoter Polymorphism of the Alpha 8 Integrin Gene and the Progression of Autosomal-Dominant Polycystic Kidney Disease"],"prefix":"10.1159","volume":"108","author":[{"given":"Raoul","family":"Zeltner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl F.","family":"Hilgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland E.","family":"Schmieder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Porst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd D.","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Hartner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,2,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2F71397"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.285.5430.1028"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2152%2Fjmi.51.1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0896-6273%2895%2990268-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.270.39.23196"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.200103069"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00662.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2800%2981903-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000082999.46030.FE"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000020592"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004670050275"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2006030234"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0955-0674%2896%2980051-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.136.6.1349"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00057.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cardiores.2006.03.003"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.89.16.7447"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yjmcc.2003.11.007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1089%2Fgte.2004.8.319"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F11.3.229"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000074653"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg292"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/116887","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/116887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:25:03Z","timestamp":1745461503000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000116887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,14]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000116887","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"type":"electronic","value":"1660-2110"}],"subject":[],"published":{"date-parts":[[2008,2,14]]}}}