{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:41:07Z","timestamp":1777927267253,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T00:00:00Z","timestamp":1203033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T00:00:00Z","timestamp":1203033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"abstract":"<jats:p>Mental performance was studied in 6 hypothyrotic patients before, seven weeks after and one year after initiation of thyroxine substitution therapy. Performance as measured by critical flicker-fusion (CFF) and vernier visual acuity (KVAT) improved significantly after 7 weeks of substitution therapy, and improved still further, although not significantly, after 1 year. Performance as measured by two reaction time tasks was not significantly improved, either after 7 weeks or after 1 year. The results were interpreted in terms of the complexity of the measures used, more complex measures being more affected by the disease through summing of several \u2018unit impairments\u2019. Further, 3 subjects were studied in detail with repeated measurements of CFF. 1 subject was studied with T4 substitution, another with T3 substitution and 1 subject with T4 substitution and T4 substitution plus T4 propylthiouracil blocking of T4 to T3 metabolism. With T4 substitution there was a distinct increase in performance, with a delay of 2-3 weeks after a dose change. With T3 substitution in a dose corresponding to T4 to T3 metabolism there was no change in performance.<\/jats:p>","DOI":"10.1159\/000117690","type":"journal-article","created":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T10:20:14Z","timestamp":1203070814000},"page":"274-281","source":"Crossref","is-referenced-by-count":7,"title":["Cerebral Function in Hypothyroid Patients"],"prefix":"10.1159","author":[{"given":"Sten","family":"Levander","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urban","family":"Rosenqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,2,15]]},"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/117690","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000117690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:39:21Z","timestamp":1777675161000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000117690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,15]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000117690","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"value":"0302-282X","type":"print"},{"value":"1423-0224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,15]]}}}