{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:01:54Z","timestamp":1792004514401,"version":"4.4.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To evaluate the outcome of the use of MgSO&lt;sub&gt;4&lt;\/sub&gt; therapy in women with severe pre-eclampsia in Kuwait from January 2002 to December 2004. &lt;i&gt;Subjects and Methods:&lt;\/i&gt; The study involved 450 women managed at the Maternity Hospital in Kuwait with a blood pressure of 160\/110 mm Hg and proteinuria of &gt;0.3\u20135 g\/24 h. A loading dose of 4 g MgSO&lt;sub&gt;4&lt;\/sub&gt; was administered intravenously over 20 min and then the maintenance dose continued at 1 g\/h for 24 h postpartum. Magnesium sulphate toxicity was monitored by urine output, deep tendon reflexes and serum magnesium levels and managed with an infusion of 10 ml of 10% calcium gluconate and cessation of magnesium infusion. Adjunct therapy included intravenous hydralazine 10 mg and labetalol 100 mg. The mode of delivery was determined after stabilizing the patient. &lt;i&gt;Results:&lt;\/i&gt; The women included Kuwaitis (n = 200, 44.4%), Asians (n = 129, 28.7%) and other Arabs (n = 116, 25.8%) with a mean age of 29.7 \u00b1 6.7 years (primigravida: n = 233, 51.8%; other parities: n = 217, 48.2%). Antenatal complications included intra-uterine growth restriction (n = 136, 30.2%), oliguria (n = 39, 8.7%), haemolysis, elevated liver enzymes and low platelet count syndrome (n = 30, 6.6%), abruptio placentae (n = 20, 4.4%), eclampsia (n = 15, 3.3%), and preterm birth (n = 253, 55.2%). Caesarean section (n = 241, 53.6%) was the main mode of delivery. The perinatal mortality rate was 27 per 1,000. Magnesium sulphate toxicity observed as reduced tendon reflexes occurred in 14 (3.1%) patients and flushing, nausea and vomiting and blocked nostrils in 86 (19.1%). There was no association between adverse outcomes and maternal serum magnesium concentrations and no maternal mortality occurred. &lt;i&gt;Conclusion:&lt;\/i&gt; Magnesium sulphate was effective in preventing recurrence of eclamptic fits and safe for both mother and fetus.<\/jats:p>","DOI":"10.1159\/000117797","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T11:22:29Z","timestamp":1207912949000},"page":"227-232","source":"Crossref","is-referenced-by-count":18,"title":["Magnesium Sulphate Therapy in Women with Pre-Eclampsia and Eclampsia in Kuwait"],"prefix":"10.1159","volume":"17","author":[{"given":"A.E.","family":"Omu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Al-Harmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.L.","family":"Vedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Mlechkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.F.","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.S.","family":"Al-Ragum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02889.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi877"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/13685530008500356"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.055"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109%2F00016349609033351"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-9861%2892%2990086-C"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320400311"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33909"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199507273330401"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2898%2900277-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2908783-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.gyobfe.2005.06.025"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F00005721-200405000-00006"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-001-9148-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200212000-00008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70221-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09290-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2008.01660.x"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/117797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/117797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:57:28Z","timestamp":1745459848000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000117797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000117797","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}