{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:29:21Z","timestamp":1791311361591,"version":"4.3.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Portal flow diversion by portacaval shunts (PCS) has been shown to prevent primary graft nonfunction in liver transplantation using small-for-size grafts. In this study, we examine whether PCS can improve reperfusion injury after major hepatectomy in pigs. &lt;i&gt;Materials and Methods:&lt;\/i&gt; In 14 pigs, a partial PCS was constructed following 65% hepatectomy and 1 h of inflow ischemia. During 24 h of reperfusion, the shunt was either closed (group A, n = 7) or left open (group B, n = 7). &lt;i&gt;Results:&lt;\/i&gt; 24 h after reperfusion, group A had higher levels of alanine aminotransferase (70 \u00b1 12 IU\/l vs. 51 \u00b1 5.9 IU\/l; p &lt; 0.05), alanine aminotransferase per gram of liver remnant (0.41 \u00b1 0.07 IU\/l\/g vs. 0.21 \u00b1 0.05 IU\/l\/g; p &lt; 0.05), prothrombin time (24.1 \u00b1 2.4 s vs. 14.3 \u00b1 2.9 s; p &lt; 0.05), international normalized ratio (2.11 \u00b1 0.15 vs. 1.29 \u00b1 0.28; p &lt; 0.05), hepatocyte necrosis scores and percentages of nuclei stained for proliferating cell nuclear antigen (52.57 \u00b1 8.9% vs. 36.71 \u00b1 6%; p &lt; 0.05) compared to group B. &lt;i&gt;Conclusions:&lt;\/i&gt; Partial portal flow diversion appears to attenuate reperfusion injury in a porcine model of major hepatectomy.<\/jats:p>","DOI":"10.1159\/000118031","type":"journal-article","created":{"date-parts":[[2008,2,27]],"date-time":"2008-02-27T11:12:47Z","timestamp":1204110767000},"page":"347-353","source":"Crossref","is-referenced-by-count":7,"title":["Effect of the Portacaval Shunt on Reperfusion Injury after 65% Hepatectomy in Pigs"],"prefix":"10.1159","volume":"40","author":[{"given":"C.","family":"Farantos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Arkadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Theodoraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kostopanagiotou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Katis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Tzavara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Andreadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Dimopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hatzoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sidiropoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Skalkidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Paphiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Smyrniotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,2,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F01.sla.0000098620.27623.7d"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jss.2005.07.028"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199505270-00005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2907593-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2005.00850.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001%2Farchsurg.136.3.280"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1432-2277.2002.tb00178.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-200302000-00015"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0039-6060%2897%2990283-X"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1006%2Fjsre.1999.5810"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199910150-00010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.freeradbiomed.2004.05.005"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-2143%2898%2990097-X"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-199903000-00011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-200012270-00006"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199901270-00024"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199910270-00009"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Flt.20317"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Flt.20164"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2004.08.027"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-200104000-00014"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-8278%2897%2980189-4"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1006%2Fjsre.1994.1140"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.510300132"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.510260619"}],"container-title":["European 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