{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:44:04Z","timestamp":1777927444847,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,2,19]],"date-time":"2008-02-19T00:00:00Z","timestamp":1203379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,2,19]],"date-time":"2008-02-19T00:00:00Z","timestamp":1203379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"abstract":"<jats:p>Previous studies have shown that slight modification of the barbitone molecule can lead to enhanced sedative activity, convulsant activity or putative antidepressant activity according to the position of the isopropyl substituent on the N- or O-moiety. When the acute effects of the N-, O&lt;sub&gt;2&lt;\/sub&gt;- and O&lt;sub&gt;4&lt;\/sub&gt;-isopropyl derivatives of barbital (NIB, O&lt;sub&gt;2&lt;\/sub&gt;IB), O&lt;sub&gt;4&lt;\/sub&gt;IB on the concentrations of brain biogenic amines were determined, it was found that NIB and O4IB increased the serotonin concentrations in several brain regions examined without markedly changing the 5-hydroxyindole acetic acid (5-HIAA) concentrations; in contrast, O&lt;sub&gt;2&lt;\/sub&gt;IB increased the 5-HIAA concentration. Barbitone and NIB raised the concentration of noradrenaline in two of the regions examined whereas the O2-substituted derivative had a smaller effect; the dopamine concentration was slightly raised by NIB and O&lt;sub&gt;2&lt;\/sub&gt;IB. Following their chronic (14 days) administration, only barbitone and O&lt;sub&gt;2&lt;\/sub&gt;IB raised the serotonin concentration; O&lt;sub&gt;2&lt;\/sub&gt;IB raised the concentration of 5-HIAA in some regions as did NIB, which suggests that these compounds may increase serotonin turnover. Barbitone and O&lt;sub&gt;2&lt;\/sub&gt;IB slightly increased the noradrenaline content of the brain stem while only O&lt;sub&gt;2&lt;\/sub&gt;IB decreased the dopamine content. These results suggest that the effects of acute and chronic administration of barbitone and its isopropyl derivatives are qualitatively different; their effects are less marked after chronic administration. The GABA concentration was only affected after chronic administration, when NIB was shown to increase and O&lt;sub&gt;2&lt;\/sub&gt;IB to decrease the concentration. Following their chronic administration, O&lt;sub&gt;2&lt;\/sub&gt;IB decreased while NIB increased the locomotor activity of rats in the \u2018open field\u2019 and \u2018hole board\u2019 apparatus. No obvious correlation could be found between the changes in brain amine concentrations and the effects of these compounds on exploratory behaviour.<\/jats:p>","DOI":"10.1159\/000118249","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T06:10:26Z","timestamp":1203487826000},"page":"95-100","source":"Crossref","is-referenced-by-count":0,"title":["Isopropyl Substitution on Barbiturate Ring: Effects on \u2018Open Field\u2019 and \u2018Hole Board\u2019 Behaviour and on Biogenic Amines Concentrations in Discrete Regions of the Rat Brain after Acute and Chronic Administration"],"prefix":"10.1159","author":[{"given":"J.F.","family":"M\u00e9nez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.E.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,2,19]]},"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/118249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000118249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:44:55Z","timestamp":1777675495000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000118249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000118249","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"value":"0302-282X","type":"print"},{"value":"1423-0224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,19]]}}}