{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:56:17Z","timestamp":1745470577752,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Delayed cerebral ischemia due to cerebral vasospasm remains a major cause of morbidity and mortality following subarachnoid hemorrhage. Oxyhemoglobin (OxyHb) and vasoconstrictor prostanoids have been suggested as putative spasmogens. We have previously reported a synergistic vasoconstrictive action between thromboxane A&lt;sub&gt;2&lt;\/sub&gt; (TXA&lt;sub&gt;2&lt;\/sub&gt;) and OxyHb. In the present study we examine the effect of neomycin, a phospholipase C inhibitor, on the cerebral vasoconstriction induced by TXA&lt;sub&gt;2&lt;\/sub&gt; and OxyHb. &lt;i&gt;Methods:&lt;\/i&gt; Using an in vitrotissue bath method, we assess the effect of neomycin in a concentration-dependent manner, on isolated porcine basilar arteries constricted by U-46619 (TXA&lt;sub&gt;2&lt;\/sub&gt; analogue) and OxyHb. &lt;i&gt;Results:&lt;\/i&gt; The functional synergism between TXA&lt;sub&gt;2&lt;\/sub&gt; and OxyHb, leading to significant cerebral vasoconstriction, is attenuated in a dose-dependent manner by neomycin. &lt;i&gt;Conclusion:&lt;\/i&gt; Blockade of phospholipase C may provide an alternative strategy in the treatment of subarachnoid-hemorrhage-induced cerebral vasospasm.<\/jats:p>","DOI":"10.1159\/000118383","type":"journal-article","created":{"date-parts":[[2008,2,27]],"date-time":"2008-02-27T11:12:47Z","timestamp":1204110767000},"page":"362-365","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Phospholipase C Blockade on Cerebral Vasospasm"],"prefix":"10.1159","volume":"25","author":[{"given":"Vikram D.","family":"Jadhav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Jabre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony Jer-Fu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.25.7.1342"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1996.84.2.0221"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000073898"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02751003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1540-8191.2001.tb01174.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-200412000-00001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0163-7258%2894%2900080-M"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-2952%2896%2900169-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0891-5849%2894%2990249-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01406495"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-2999%2889%2990565-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-3019%2891%2990228-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0024-3205%2897%2900682-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-3019%2891%2990042-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0008-6363%2895%2900137-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.2006.105.2.288"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ceca.2007.04.010"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0508781103"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/118383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/118383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:04:26Z","timestamp":1745460266000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000118383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000118383","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"type":"print","value":"1015-9770"},{"type":"electronic","value":"1421-9786"}],"subject":[],"published":{"date-parts":[[2008]]}}}