{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:49:17Z","timestamp":1782514157244,"version":"3.54.5"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T00:00:00Z","timestamp":1203465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T00:00:00Z","timestamp":1203465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"abstract":"<jats:p>The platelet serotonin uptake kinetics was studied in 19 women with premenstrual tension syndrome (PMS) and 19 age-matched symptom-free controls during the pre- and postmenstrual phases. Both groups exhibited stable V&lt;sub&gt;max&lt;\/sub&gt; and K&lt;sub&gt;m&lt;\/sub&gt; values at the two phases of the menstrual cycle. There were no differences between the two groups regarding the level of V&lt;sub&gt;max&lt;\/sub&gt; and K&lt;sub&gt;m&lt;\/sub&gt;, respectively. The effect of season (p &lt; 0.001), with lowered values of V&lt;sub&gt;max&lt;\/sub&gt; during spring compared to corresponding values during the later half of the year, was identical in both groups. A tendency to lowered V&lt;sub&gt;max&lt;\/sub&gt; values in the follicular phase in women with PMS during spring may indicate that women with PMS are more vulnerable to developing depressive episodes during this period than symptom-free women. The blood platelet count in whole blood was decreased in the luteal phase in the control group but remained stable in the PMS group. The effect of vitamin B&lt;sub&gt;6&lt;\/sub&gt; on clinical symptoms and the platelet serotonin uptake during the luteal phase was investigated in a double-blind crossover design. Vitamin B&lt;sub&gt;6&lt;\/sub&gt; treatment did not significantly improve the PMS symptoms. There was no effect of treatment on K&lt;sub&gt;m&lt;\/sub&gt;. V&lt;sub&gt;max&lt;\/sub&gt; increased significantly in response to treatment (F = 9.6; p &lt; 0.001) in both groups, but there was no significant difference between placebo and vitamin B&lt;sub&gt;6&lt;\/sub&gt;.<\/jats:p>","DOI":"10.1159\/000118398","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T06:10:26Z","timestamp":1203487826000},"page":"83-88","source":"Crossref","is-referenced-by-count":25,"title":["Platelet Serotonin Uptake and Effects of Vitamin B\n                    <sub>6<\/sub>\n                    -Treatment in Premenstrual Tension"],"prefix":"10.1159","author":[{"given":"Rigmor","family":"Malmgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aila","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl-Gustaj","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,2,20]]},"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/118398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000118398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:46:26Z","timestamp":1777675586000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000118398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000118398","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"value":"0302-282X","type":"print"},{"value":"1423-0224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,20]]}}}