{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:56:25Z","timestamp":1745470585893,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Activity of simulated serum concentrations after oral therapy with 400 mg cefditoren pivoxil b.i.d., 500 mg cefuroxime axetil b.i.d. and 875\/125 mg amoxicillin\/clavulanic acid b.i.d. and t.i.d. regimens was explored over 24 h against &lt;i&gt;Streptococcus pneumoniae.&lt;\/i&gt;&lt;i&gt;Methods:&lt;\/i&gt; Computerized pharmacodynamic simulations were performed against strains with penicillin\/amoxicillin\/cefuroxime\/cefditoren minimum inhibitory concentrations (MICs, \u00b5g\/ml) and serotypes: strain 1 (0.25\/0.12\/1\/0.12; serotype 6A), strain 2 (2\/4\/ 2\/0.25; serotype 6B), strain 3 (4\/16\/4\/0.5; serotype 14), and strain 4 (4\/16\/8\/1; serotype 14). &lt;i&gt;Results:&lt;\/i&gt; Bactericidal activity (\u22673 log&lt;sub&gt;10&lt;\/sub&gt; reduction) at 12 and 24 h was obtained against all strains with cefditoren, against strains 1 and 2 with cefuroxime and amoxicillin\/clavulanic acid t.i.d., but only against strain 1 with amoxicillin\/clavulanic acid b.i.d.. Bactericidal activity at 24 h was related to T &gt; MIC of &gt;30% dosing interval, 1.7\u20132.0 log&lt;sub&gt;10&lt;\/sub&gt; reductions with T &gt; MIC of 20\u201330%, and &lt;1 log&lt;sub&gt;10&lt;\/sub&gt; reduction or regrowth with T &gt; MIC of 0%. &lt;i&gt;Conclusions:&lt;\/i&gt; It is difficult to achieve pharmacodynamic coverage and bactericidal activity by physiological concentrations of oral \u03b2-lactams against penicillin-resistant pneumococcal strains exhibiting higher amoxicillin versus penicillin MICs. Cefditoren may offer alternatives.<\/jats:p>","DOI":"10.1159\/000118659","type":"journal-article","created":{"date-parts":[[2008,2,22]],"date-time":"2008-02-22T11:25:15Z","timestamp":1203679515000},"page":"84-90","source":"Crossref","is-referenced-by-count":5,"title":["\u03b2-Lactam Activity against Penicillin-Resistant &lt;i&gt;Streptococcus pneumoniae&lt;\/i&gt; Strains Exhibiting Higher Amoxicillin versus Penicillin Minimum Inhibitory Concentration Values: An in vitro Pharmacodynamic Simulation"],"prefix":"10.1159","volume":"54","author":[{"given":"D.","family":"Sevillano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Alou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Gim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Echeverr\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Torrico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Valdes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Coronel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.49.5.1965-1972.2005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.47.11.3637-3639.2003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1086%2F321847"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkh463"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fbdd.2510080604"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkg082"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkf163"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-0691.2007.01777.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000048551"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.48.2.369-377.2004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijantimicag.2006.08.046"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS1201-9712%2803%2990066-X"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000097608"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000049179"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/118659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/118659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:06:52Z","timestamp":1745460412000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000118659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000118659","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2008]]}}}