{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:37:24Z","timestamp":1778704644277,"version":"3.51.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>The aim of this study was to estimate prognostic factors in a Dalmatian dog with bilateral cryptorchidism and hypospadias. Cytogenetic and molecular analyses revealed a normal karyotype (2n = 78,XY) and the presence of &lt;i&gt;SRY, INSL3&lt;\/i&gt; and &lt;i&gt;RXFP2 &lt;\/i&gt;genes with a normal DNA sequence for &lt;i&gt;SRY&lt;\/i&gt; and &lt;i&gt;RXFP2&lt;\/i&gt;, while the &lt;i&gt;INSL3&lt;\/i&gt; sequence differed slightly from the normal one due to a heterozygous nucleotide change involving amino acid 22 of the INSL3 dog precursor protein. Levels of plasmatic testosterone were only 0.01 ng\/ml, while FSH and LH serum levels were not detectable. After the human chorionic gonadotropin (hCG) test, the serum testosterone level was 0.01 ng\/ml. Therefore, the phenotypic aetiology of this subject can not be well-defined because cryptorchidism and hypospadias were frequent clinical features with high genetic heterogeneity.<\/jats:p>","DOI":"10.1159\/000118753","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T09:35:09Z","timestamp":1209548109000},"page":"140-143","source":"Crossref","is-referenced-by-count":19,"title":["Clinical, cytogenetic and molecular evaluation in a dog with bilateral cryptorchidism and hypospadias"],"prefix":"10.1159","volume":"120","author":[{"given":"R.","family":"Cassata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Iannuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Parma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"De Lorenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Peretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Perucatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Iannuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.P.","family":"Di Meo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1530%2FREP-06-0272"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1439-0264.1981.tb00508.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Ftera.1420180208"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F11.19.2309"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Ftera.1420320108"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.1579"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2F10364"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1907"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Ftera.1420120107"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod.103.019166"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fme.13.5.681"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/118753","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/118753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:08:08Z","timestamp":1745460488000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000118753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":11,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2008,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000118753","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5120365","asserted-by":"subject"}]},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"value":"1424-8581","type":"print"},{"value":"1424-859X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}