{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:56:39Z","timestamp":1745470599789,"version":"3.40.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T00:00:00Z","timestamp":1205366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T00:00:00Z","timestamp":1205366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Gastroenterol"],"abstract":"<jats:p>&lt;i&gt;Herpes simplex&lt;\/i&gt; infection is characterized by acute or subacute infection, often followed by a chronic carrier state. Consecutive recurrences may flare up if immunocompromise occurs. &lt;i&gt;Herpes simplex&lt;\/i&gt; associated esophagitis or duodenal ulcer have been reported in immunocompromised patients due to neoplasm, HIV\/AIDS or therapeutically induced immune deficiency. Here we report the case of an HSV-DNA seronegative patient who developed grade III dysphagia 13 days after allogeneic liver transplantation. Endoscopy revealed an esophageal-gastric ulcer, and biopsy histopathology showed a distinct fibroplastic and capillary ulcer pattern highly suspicious for viral infection. Immunohistochemistry staining revealed a distinct nuclear positive anti-HSV reaction. Antiviral therapy with acyclovir and high-dose PPI led to a complete revision of clinical symptoms within 48 h. Repeat control endoscopy after 7 days showed complete healing of the former ulcer site at the gastroesophageal junction. Although the incidence of post-transplantation &lt;i&gt;Herpes simplex&lt;\/i&gt; induced gastroesophageal disease is low, the viral HSV ulcer may be included into a differential diagnosis if dysphagia occurs after transplantation even if HSV-DNA PCR is negative.<\/jats:p>","DOI":"10.1159\/000119113","type":"journal-article","created":{"date-parts":[[2008,3,14]],"date-time":"2008-03-14T11:35:25Z","timestamp":1205494525000},"page":"103-108","source":"Crossref","is-referenced-by-count":0,"title":["Seronegative &lt;i&gt;Herpes simplex&lt;\/i&gt; Associated Esophagogastric Ulcer after Liver Transplantation"],"prefix":"10.1159","volume":"2","author":[{"given":"Edouard","family":"Matevossian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietrich","family":"Doll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Weirich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Burian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"Knebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Thorban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"H\u00fcser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1020122924580"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Flt.20219"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1620%2Ftjem.195.61"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1746.2003.03166.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2006.02.100"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00336466"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00535-002-1186-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM197706162962402"}],"container-title":["Case Reports in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/119113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/119113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:12:15Z","timestamp":1745460735000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000119113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,13]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000119113","archive":["Portico"],"relation":{},"ISSN":["1662-0631"],"issn-type":[{"type":"electronic","value":"1662-0631"}],"subject":[],"published":{"date-parts":[[2008,3,13]]}}}