{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:23:35Z","timestamp":1774675415774,"version":"3.50.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> No consistent data are available regarding the effect of inhaled corticosteroids (ICS) in \u03b1<sub>1<\/sub>-antitrypsin-deficiency (AATD)-related COPD. Recent data report inflammatory effects of the polymers of \u03b1<sub>1<\/sub>-antitrypsin on the peripheral lung. <i>Objectives:<\/i> The aim of this study was to assess the effectiveness of an extra-fine ICS, hydrofluoroalkane-134a beclometasone dipropionate (HFA-BDP) with a mass median aerodynamic diameter of 1.1 \u00b5m, on lung function and exercise tolerance in COPD patients with AATD when added to long-acting bronchodilators (LABAs). <i>Methods:<\/i> After a 1-week washout, 8 steroid-na\u00efve COPD patients with AATD (ZZ genotype), within a double-blind randomized cross-over study, were assigned to one of the following 16-week treatments: (1) HFA-BDP 400 \u00b5g b.i.d., salmeterol 50 \u00b5g b.i.d. and oxitropium bromide 200 \u00b5g t.i.d. or (2) placebo, salmeterol 50 \u00b5g b.i.d. and oxitropium bromide 200 \u00b5g t.i.d; after a 2-week washout period they received the other treatment. In weeks 1, 17, 19 and 35, patients took a spirometry assessment (breathing air and heliox) and a shuttle walking test (SWT) with dyspnea assessed by the modified Borg scale. <i>Results:<\/i> Significant differences in improvement were found in FEV<sub>1<\/sub>, FVC, IC, distance covered and dyspnea perceived during SWT between the 2 treatments and baseline values (p < 0.05; Friedman\u2019s test). However, further analysis showed that only the LABAs + ICS condition showed significant increases in the FEV<sub>1<\/sub>, FVC, IC, \u0394MEF<sub>50%<\/sub> and distance covered during SWT along with a reduction in maximum isostep exertional dyspnea (p < 0.05; Wilcoxon test). A greater distance was walked at the end of the SWT with LABA + ICS than LABAs alone (301 \u00b1 105 vs. 270 \u00b1 112 m; p < 0.05). <i>Conclusions:<\/i> In AATD-related COPD patients (ZZ genotype) the addition of extra-fine ICS to LABAs decreases airway narrowing, mostly in the small airways, further reducing dynamic hyperinflation with a marked improvement in exercise tolerance and dyspnea, suggesting that a peripheral inflammatory process contributes to airflow obstruction in these patients.<\/jats:p>","DOI":"10.1159\/000119718","type":"journal-article","created":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T13:17:23Z","timestamp":1204550243000},"page":"61-68","source":"Crossref","is-referenced-by-count":20,"title":["Inhaled Corticosteroids as Additional Treatment in Alpha-1-Antitrypsin-Deficiency-Related COPD"],"prefix":"10.1159","volume":"76","author":[{"given":"Luciano","family":"Corda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica","family":"Bertella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe Emanuele","family":"La Piana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Boni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Redolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Tantucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2966781-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000088061"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000105536"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.humpath.2004.08.013"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM197806082982303"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.117.5_suppl_1.250S"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.117.5_suppl_1.291S"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0954-6111%2897%2990030-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.98.12061346"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-3003.2000.15d22.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.47.12.1019"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1513%2Fpats.200603-078AW"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.277.5334.2002"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI115391"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fthorax.57.8.709"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200511-1797PP"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/119718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/119718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:19:05Z","timestamp":1745461145000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000119718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000119718","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}